Researcher

    Baruch Toledano , M.D. , FRCPC

    baruch_toledano@ssss.gouv.qc.ca
    Address
    CHUSJ

    Phone
    514 345-4931 #3260

    Fax
    514 345-4822

    Online

    Title

    • Clinical Assistant Professor, Department of Pediatrics, University of Montreal.

    Education

    • MD, McGill University, 1989.

    Research Interests

    Among other research topics, Baruch Toledano is examining the immune system response to immune modulators. He is also interested in discovering the significant factors involved in adverse effects following cardiopulmonary bypass. The prevalence of congenital heart defects is 8 for every 1000 live births. Most of these children will need to undergo a cardiopulmonary bypass to repair this defect. Cardiopulmonary bypass, especially in children, is linked with significant inflammation, thus resulting in neutrophil activation and causing cellular lesions.

    This exagerated inflammatory response can be observed in all newborns, while being present in only 5% of adults needing bypass surgery. The neutrophil seems to act as an essential mediator of tissue lesions associated with cardiopulmonary bypass and its related morbidity and mortality. Programmed cell death, or apoptosis, is a mechanism which controls the functional longevity of neutrophils found in tissues. Enhanced knowledge of modifications induced during neutrophil cell apoptosis, in addition to the eventual elimination of the inflammation effects brought on by this response, are crucial notions to the understanding of bypass tissue lesions.

    Baruch Toledano and his team are working to answer questions regarding the newborn’s intrinsic susceptibility to display an aggravated inflammatory reaction responsible for the rise of morbidity and mortality rates associated with bypass surgery. With the appropriate patient modulations, it would be possible to force programmed neutrophil cellular death in order to avoid inflammatory response. This would result in reduced organ dysfunction symptoms and improved infant survival rates following bypass.

    In addition, the team is studying the herpes simplex virus (HSV), the most frequent cause of sporadic viral encephalitis in North America. The host response to the herpes simplex virus is more frequently morbid or mortal in newborns than it is in adults. As of yet, there is no data to determine the infection effects of the herpes simplex virus 1 on apoptosis of neonatal neutrophilic cells.

 

Grow Beyond our wildest dreams

With the support of donors like you, at the heart of the Grow Beyond campaign, we are leading healthcare teams towards the opportunities offered by science and new technologies, so that every child, no matter where in Quebec, has access to the unique expertise and know-how of CHU Sainte-Justine. Together, let's join forces for their future.

Grow Beyond with us.

Contact Us

514 345-4931

Légal

© 2006-2014 CHU Sainte-Justine.
All rights reserved.
Terms of Use, Confidentiality, Security

Avertissement

Les informations contenues dans le site « CHU Sainte-Justine » ne doivent pas être utilisées comme un substitut aux conseils d’un médecin dûment qualifié et autorisé ou d’un autre professionnel de la santé. Les informations fournies ici le sont à des fins exclusivement éducatives et informatives.

Consultez votre médecin si vous croyez être malade ou composez le 911 pour toute urgence médicale.

CHU Sainte-Justine