Researcher

Title

• Head of pediatric neurology service, 2018
• Associate Professor, Department of Pediatrics, Faculty of Medicine, Université de Montréal, 2014

• Fellowship in pediatric neurology and tuberous sclerosis complex, Massachusetts General Hospital, Harvard University, 2006-2008
• Specialty in pediatric neurology, CHU Sainte-Justine, Université de Montréal, 2001-2006

• Epilepsy
• Tuberous sclerosis complex

Career Summary

Dr Philippe Major finished his residency in Pediatric Neurology at the CHU Sainte-Justine in 2006. He then completed a fellowship in Pediatric Epilepsy at the Massachusetts General Hospital in 2008, where he was responsible for the Tuberous Sclerosis Complex (TSC) Clinic. Since 2008, he leads the first Canadian TSC clinic.  He is interested about the many clinical manifestations of this disease, in particular about its neurological impacts (epilepsy, intellectual and developmental delay, autistic spectrum disorder, psychiatric manifestations).

His research projects focus also on many forms of epilepsy, from benign to refractory types.

Dr Major has also been director of the residency program in pediatric neurology from 2012 to 2018 and he is now head of the pediatric neurology service.  

Awards and Distinctions

• Organization of an international joint meeting on Tuberous Sclerosis Complex and Neurofibromatosis, CHU Sainte-Justine, Montréal, May 11th 2018

Presentations

• "Impacts of epilepsy on development", Congrès de physiothérapie pédiatrique, CHU Sainte-Justine, Montréal, October 6th, 2017
• "Use of mTOR inhibitors in patients with tuberous sclerosis complex", McGill University Health Center, March 15th, 2017
• "New treatment for patients with tuberous sclerosis complex: the importance of a multidisciplinary approach", Department of medicine, Hôpital Maisonneuve-Rosemont, Montréal, March 26th, 2015
• "New therapeutic strategies for patients with tuberous sclerosis complex", Hôpital de l’Enfant-Jésus de Québec, March 12th, 2015

Publications

PubMed

• 1. Major P, Lortie A, Dehaes M, Lodygensky GA, Gallagher A, Carmant L, Birca A. Periictal activity in cooled asphyxiated neonates with seizures. Seizure. 2017 Apr;47:13-16
  2. Kaseka ML, Bitton JY, Décarie JC, Major P. Predictive Factors for Epilepsy in Pediatric Patients With Sturge-Weber Syndrome. Pediatr Neurol. 2016 Nov;64:52-58
  3. Goyer I, Dahdah N, Major P. Use of mTOR inhibitor everolimus in three neonates for treatment of tumors associated with tuberous sclerosis complex. Pediatr Neurol. 2015 Apr;52(4):450-3
  4. Major P. Potential of mTOR inhibitors for the treatment of subependymal giant cell astrocytomas in tuberous sclerosis complex. Aging (Albany NY). 2011 Mar;3(3):189-91.
  5. Birca A, Mercier C, Major P. Rapamycin as an alternative to surgical treatment of subependymal giant cell astrocytomas in a patient with tuberous sclerosis complex. J Neurosurg Pediatr. 2010 Oct;6(4):381-4.