Researcher

Title

• Clinical Assistant Professor, Department of Neurosciences, Faculty of Medicine, Université de Montréal, 2014
• Clinical Researcher, CHU Sainte-Justine, 2015
• Director of the pediatric neurology program, CHU Sainte-Justine, 2018

Internship opportunity(ies)

• MSc or PhD position in Radio-oncology and Magnetic Resonance Imaging (MRI)

• Fellowship in neuro-oncology, Stanford University, Lucile Packard Children’s Hospital, California, USA, 2011/07 - 2013/06
• Residency in Child Neurology, CHU Sainte-Justine, 2006/07 - 2011/06
• Medicine, Université de Montréal, 2000/07 - 2006/05
• Master in Neurological Sciences, Université de Montréal, 2003/07 - 2005/06

Career Summary

Dr. Sébastien Perreault joined the Child Neurology service at CHU Sainte-Justine. After his residency,he completed a fellowship in pediatric neuro-oncology at Stanford University in California. He developped an expertise in treatment and long term follow-up of patients with brain tumor and neurological complications of chemotherapy and radiation therapy.

He is currently conducting a pan-Canadian, multicentre phase II study of the treatment of refractory low-grade gliomas and plexiform neurofibromas with trametinib’imatinib mesylate. This study is supported by a CIHR grant. Dr. Perreault has developed expertise in targeted therapy for low grade gliomas and is actively participating in several international studies. Her research also focuses on improving the management of patients with neurofibromatosis and the evaluation of vision in patients with optic glioma.

Research topics

• Neuro-oncology
• Targeted therapy
• Low grade glioma
• Plexiform Neurofibroma
• Child Neurology

Awards and Distinctions

• Prix Guy Geoffroy, Excellence in teaching award, CHU Sainte-Justine, 2013/7 - 2014/6
• Beverly and Bernard Fellowship, Lucile Packard Children's Hospital (Stanford), 2011/7 - 2013/7
• Prix Claude Roy, Excellence in research during residency, CHU Sainte Justine, 2006/7 - 2011/6
• Dean’s List, Pediatric Neurology, Université de Montréal, 2006/7 - 2011/6              
• Dean’s List, Medicine, Université de Montréal, 2001/7 - 2006/6

Presentations

Guest speaker

• 2019, Larotrectinib in pediatric TRK cancer. CNS Grand Round. Montréal, Québec, 7 octobre 2019
• 2019, Thérapie ciblée en neuro-oncologie pédiatrique. Congrès Annuel de l’Association des Neurologues du Québec, Sainte-Marguerite du Lac Masson, Québec, 7 septembre 2019
• 2017, Thérapie ciblée en neuro-oncologie pédiatrique. Congrès annuel des neuro-chirurgiens du Québec, Québec, 3 novembre 2017.
• 2017, Tumeurs cérébrales pédiatriques: types de tumeurs, effets secondaires des traitements et recherché.  Journée de la fondation Canadienne des Tumeurs Cérébrales, Montréal, 28 octobre 2017.
• 2017, Hot topics in neuro-oncologie. Conférence annuelle de Canadian Neurological Science Federation. Victoria, British Columbia, Canada
• 2017, Traitement des neurofibromes plexiformes. Journée annuelle de l’Association de neurofibromatose du Québec, Montréal, Canada
• 2016, Gliomes des voies optiques et neurofibromes plexiformes chez les patients avec NF1.  Journée annuelle de l’Association de neurofibromatose du Québec, Montréal, Canada

Publications

1. Philippe L, Maria K, Tariq A, Sofia M, Christine SM, Jean-Pierre F, Dudley RW, Sébastien P, Nada J, Valérie L. Efficacy of Dabrafenib for three children with brainstem BRAFV600E positive ganglioglioma. J Neurooncol. 2019 Oct;145(1):135-141
2. Rassi SZ, Ospina LH, Bochereau A, Samson Y, Perreault S, Saint-Amour D. Central and peripheral steady-state visual evoked potentials in children with optic pathway gliomas. Doc Ophthalmol. 2019 Oct;139(2):137-149.
3. Robert-Boire V, Desnous B, Lortie A, Carmant L, Ellezam B, Weil AG, Perreault S. Seizures in Pediatric Patients With Primary Brain Tumors.Pediatr Neurol. 2019 Aug;97:50-55.
4. Khater F, Langlois S, Cassart P, Roy AM, Lajoie M, Healy J, Richer C, St-Onge P, Piché N, Perreault S, Cellot S, Marzouki M, Jabado N, Sinnett D.  Recurrent somatic BRAF insertion (p.V504_R506dup): a tumor marker and a potential therapeutic target in pilocytic astrocytoma.  Oncogene. 2018 Dec 21. doi: 10.1038/s41388-018-0623-3. [Epub ahead of print]
5. Kondyli M, Larouche V, Saint-Martin C, Ellezam B, Pouliot L, Sinnett D, Legault G, Crevier L, Weil A, Farmer JP, Jabado N, Perreault S.  Trametinib for progressive pediatric low-grade gliomas.  J Neurooncol. 2018 Nov;140(2):435-444. 
6. Rosca L, Robert-Boire V, Delisle JF, Samson Y, Perreault S.  Carboplatin and vincristine neurotoxicity in the treatment of pediatric low-grade gliomas.  Pediatr Blood Cancer. 2018 Nov;65(11):e27351.
7. Weil AG, Muir K, Hukin J, Desautels A, Martel V, Perreault S.  Narcolepsy and Hypothalamic Region Tumors: Presentation and Evolution.  Pediatr Neurol. 2018 Jul;84:27-31
8. Leal Ferman LA, Daigle P, Weil A, Ellezam B, Hamel P, Perreault S. Embryonal Tumor with Multilayered Rosettes Presenting with Intermittent Third Nerve Palsy.  Can J Neurol Sci. 2018 Jul;45(4):483-484.
9. Domon-Archambault V, Gagnon L, Benoît A, Perreault S.  Psychosocial Features of Neurofibromatosis Type 1 in Children and Adolescents.  J Child Neurol. 2018 Mar;33(3):225-232.
10. Robert-Boire V, Rosca L, Samson Y, Ospina LH, Perreault S.  Clinical Presentation and Outcome of Patients With Optic Pathway Glioma. Pediatr Neurol. 2017 Oct;75:55-60.
11. D'Aronco L, Rouleau C, Gayden T, Crevier L, Décarie JC, Perreault S, Jabado N, Bandopadhayay P, Ligon KL, Ellezam B.  Brainstem angiocentric gliomas with MYB-QKI rearrangements.  Acta Neuropathol. 2017 Oct;134(4):667-669.
12. Weil AG, Wang AC, Westwick HJ, Ibrahim GM, Ariani RT, Crevier L, Perreault S, Davidson T, Tseng CH, Fallah A.  Survival in pediatric medulloblastoma: a population-based observational study to improve prognostication. J Neurooncol. 2017 Mar;132(1):99-107.
13. Bernier A, Larbrisseau A, Perreault S.  Café-au-lait Macules and Neurofibromatosis Type 1: A Review of the Literature.  Pediatr Neurol 2016 Jul;60:24-29.
14. Phoenix TN, Patmore DM, Boop S, Boulos N, Jacus MO, Patel YT, Roussel MF, Finkelstein D, Goumnerova L, Perreault S, Wadhwa E, Cho YJ, Stewart CF, Gilbertson RJ. Medulloblastoma Genotype Dictates Blood Brain Barrier Phenotype. Cancer Cell. 2016 Apr 11;29(4):508-522.
15. Perreault S, Lober RM, Davis C, Stave C, Partap S, Fisher PG. Sports and childhood brain tumors: Can I play? Neurooncol Pract 2014;1(4):158-165.
16. Perreault S, Ramaswamy V, Achrol, Chao K, Ting Liu T, Shih D, Remke M, Schubert S, Bouffet E, Fisher PG, Partap S, Vogel H, Taylor MD, Cho YJ, Yeom KW. MRI surrogates for molecular subgroups of medulloblastoma. Am J Neuroradiol 2014;35(7):1263-1269.
17. Perreault S, Lober RM, Zhang G, Hershon L, Decarie J-C, Yeom K, Vogel H, Carret A-S, Fisher PG, Partap S. Surveillance imaging in children with malignant CNS tumors: low yield of spine MRI. J Neurooncol, 2014 Feb;116(3):617-23.
18. Perreault S, Lober RM, Cheshier S, Edwards MSB, Partap S, Yeom KW. Time-dependent Structural Changes of the Dentate Nuclei and Dentatothalamic Tract in Children Treated for Posterior Fossa Tumor. Am J Neuroradiol 2014;35(4):803-7
19. Perreault S, Lober RM, Zhang G, Hershon L, Decarie J-C, Yeom K, Vogel H, Carret A-S, Fisher PG, Partap S. Different relapse patterns in embryonal CNS tumors. J Neurooncol. 2013 Nov;115(2):209-15.