Researcher

    Carolina Alfieri , Ph.D.

    carolina.alfieri@recherche-ste-justine.qc.ca
    Carolina Alfieri
    Research Axis
    Viral and Immune Disorders and Cancers
    Research Theme
    Infection and immunity
    Address
    CHUSJ - Centre de Recherche

    Phone
    514 345-4931 #6135

    Fax
    514 345-4801

    Career Summary

    Our research has focused on the biology of Epstein-Barr virus (EBV) infection and EBV-induced B-cell lymphoproliferation in immunocompromised patients. Our laboratory was the first to demonstrate a direct correlation between EB viral load and development of post-transplant lymphoproliferative disease (PTLD). This finding has had an important impact on the diagnosis/prognosis and pre-emptive management of PTLD. A follow-up study demonstrated that a second marker can be used in conjunction with EB viral load to better define patients at high risk for PTLD. More recently, our laboratory has developed a deoxyribozyme antiviral with catalytic activity against the hepatitis C virus (HCV). This deoxyribozyme was shown to cleave HCV RNA efficiently in cells transfected with the full-length HCV genome. In vivo collaborative studies using an infectious mouse model are now in progress to investigate the potential clinical application of our deoxyribozyme.

About this page
Edited by Hoffmann Maude

Created on 9/18/2014
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