Carolina Alfieri , Ph.D.
    Carolina Alfieri
    Research Axis
    Infectious Diseases and Acute Care Axis
    Research Theme
    Infection, immunity and inflammation
    CHUSJ - Centre de Recherche

    514 345-4931 #6135

    514 345-4801

    Career Summary

    Our research has focused on the biology of Epstein-Barr virus (EBV) infection and EBV-induced B-cell lymphoproliferation in immunocompromised patients. Our laboratory was the first to demonstrate a direct correlation between EB viral load and development of post-transplant lymphoproliferative disease (PTLD). This finding has had an important impact on the diagnosis/prognosis and pre-emptive management of PTLD. A follow-up study demonstrated that a second marker can be used in conjunction with EB viral load to better define patients at high risk for PTLD. More recently, our laboratory has developed a deoxyribozyme antiviral with catalytic activity against the hepatitis C virus (HCV). This deoxyribozyme was shown to cleave HCV RNA efficiently in cells transfected with the full-length HCV genome. In vivo collaborative studies using an infectious mouse model are now in progress to investigate the potential clinical application of our deoxyribozyme.


Every dollar counts!

Thank you for your generosity.

It's people like you that allow us to accelerate research and heal more children better every year and, as such, offer among the best healthcare in the world.

It's also possible to give by mail or by calling toll-free

1-888-235-DONS (3667)

Contact Us

514 345-4931


© 2006-2014 CHU Sainte-Justine.
All rights reserved.
Terms of Use, Confidentiality, Security


Les informations contenues dans le site « CHU Sainte-Justine » ne doivent pas être utilisées comme un substitut aux conseils d’un médecin dûment qualifié et autorisé ou d’un autre professionnel de la santé. Les informations fournies ici le sont à des fins exclusivement éducatives et informatives.

Consultez votre médecin si vous croyez être malade ou composez le 911 pour toute urgence médicale.

CHU Sainte-Justine