Elie Haddad , M.D. , Ph.D.
    Elie Haddad
    Research Axis
    Immune Diseases and Cancer Axis
    Research Theme
    Immune diseases: mechanisms, new therapeutic approaches and disease outcomes
    CHUSJ - Centre de Recherche Office 6.17.003

    514 345-4931 #6217

    514 345-4897


    • Full Professor, Department of Pediatrics, Department of Microbiology, Immunology et Infectiology, Faculty of Medicine, University of Montreal
    • Clinician, Immuno-Allergy and Rheumatology Division, CHU Sainte-Justine

    Research Interests

    • Immune diseases: mechanisms, new therapeutic approaches and disease outcomes
    • Cancer Immunotherapy
    • Precision Medicine, Gene Therapy 

    Career Summary

    Dr. Haddad is a clinician-researcher in pediatric immunology, full professor at the University of Montreal, head of the Immunology and Rheumatology department at CHU Ste-Justine. Conducting both clinical and basic research, he is an internationally recognized expert in the field of immune deficiencies, hematopoietic stem cell transplantation, cellular therapy and humanized mouse technology.

    With an h-index of 65 and an i10-index of 155, he has published 205 peer-reviewed articles, which have been cited more than 14,800 times. His research has been continually supported by funds from provincial, national and international organizations, including the FRQS, CIHR, NSERC and NIH.

    His research program is at the crossroads between clinic and research, which allows the understanding of mechanisms of immune diseases, the improvement of treatments already in use and the development of new therapeutic strategies. His translational research program, which combines clinical and fundamental research, is divided into 4 main themes:

    • Research on cytotoxic immune cells, mainly Natural Killer (NK) cells
    • Genetic engineering for cancer immunotherapy, based on chimeric antigen receptor (CAR) and synthetic specific promoter technologies, and notably exploiting the potential of NK cells and hematopoietic stem cells (HSC)
    • Modeling of immune-mediated diseases, both immunodeficiencies and immune dysregulation (viral and autoimmune), using humanized mouse models
    • Primary immune deficiencies and hematopoietic stem cell biology in a context transplantation and gene therapy.

    Awards and Distinctions

    • Best young investigator in Pediatric Research, Fondation des étoiles, 2011
    • Research award of the department of Pediatrics of the University of Montreal, 2015
    • Fellow of the Canadian Academy of Health Science, 2022
    • Academic Leadership Clinician Investigator Award of the Pediatric Chairs of Canada, 2022
    • President of the « Clinical Immunology Society », 2023
    • Jerry Dolovich Award from the Canadian Society of Allergy and Clinical Immunology, 2023


    • Knutsen A.P., Goldman F.D., Aquino V.M., Shereck E.B., Moore T.B., Caywood E.H., Lugt M.T.V., Rozmus J., Broglie L., Yu L.C., Shah A.J., Andolina J.R., Liu X., Parrott R.E., Dara J., Prockop S., Martinez C.A., Kapadia M., Jyonouchi S.C., Sullivan K.E., Bleesing J.J., Chaudhury S., Petrovic A., Keller M.D., Quigg T.C., Parikh S., Shenoy S., Seroogy C., Rubin T., Decaluwe H., Routes J.M., Torgerson T.R., Leiding J.W., Pulsipher M.A., Kohn D.B., Griffith L.M., Haddad E*., Dvorak C.C.*, Notarangelo L.D.* : Measuring the effect of newborn screening on survival after haematopoietic cell transplantation for severe combined immunodeficiency: a 36-year longitudinal study from the Primary Immune Deficiency Treatment Consortium. Lancet. 2023 Jul 8;402(10396):129-140. PubMed PMID: 37352885. https// 
      * Co-senior auteur
    • Mac Donald A. Guipouy D., Lemieux W., Harvey M., Bordeleau L-J, Guay D., Roméro H, Li Y., Dion, R., Béland K., Haddad E. (2023). KLRC1 knockout overcomes HLA-E-mediated inhibition and improves NK cell antitumor activity against solid tumors. Frontiers in Immunology. 14: Volume 14 - 2023 |
    • Colas C., Volodina O., Béland K., Pham T.N.Q., Li Y., Dallaire F., Soulard C., Lemieux W., Colamartino A.B.L., Tremblay-Laganière C., Dicaire R., Guimond J., Vobecky S., Poirier N., Patey N., Cohen E.A. and Haddad E. Generation of Functional Human T Cell Development in NOD/SCID/IL2rγnull Humanized Mice Without Using Fetal Tissue: Application as a Model of HIV Infection and Persistence. Stem Cell Reports, 2023, vol 18, p. 597–612.  
    • Bifsha P, Leiding JW, Pai SY, Colamartino ABL, Hartog N, Church JA, Oshrine BR, Puck JM, Markert ML, Haddad E. Diagnostic assay to assist clinical decisions for unclassified severe combined immune deficiency. Blood Advances. 2020, 4(12): 2606-2610.
    • Colamartino A. BL., Lemieux W., Bifsha P., Nicoletti S.,Chakravarti N., Sanz J, Romero H., Selleri, S., Beland K., Guiot M.R., Tremblay-Laganière C., Dicaire R., Barreiro L., Lee D.A.,Verhoeyen E. and Haddad E. Efficient and Robust NK-Cell Transduction With Baboon Envelope Pseudotyped Lentivector. Frontiers in Immunology. 2019, vol 10 (2873)
    • Kebir H., Carmant L., Fontaine F, Béland K, Bosoi C., Sanon N., Alvarez J.I., Desgent S., Pittet C., Hébert D., Langlois MJ, Rébillard RM, Nguyen D.K., Cieuta C., Holmes G.L., Goodkin H.P., Mytinger J.R., Connolly M.B., Prat A., Haddad E.; Humanized mouse model of Rasmussen’s encephalitis supports the immune-mediated hypothesis. J Clin Invest. 2018, 128(5): 2000-2009.
    • Haddad E, Logan BR, Griffith LM, Buckley RH, Parrott RE, Prockop SE, Small TN, Chaisson J, Dvorak CC, Murnane M, Kapoor N, Abdel-Azim H, Hanson IC, Martinez C, Bleesing JJH, Chandra S, Smith AR, Cavanaugh ME, Jyonouchi S, Sullivan KE, Burroughs L, Skoda-Smith S, Haight AE, Tumlin AG, Quigg TC, Taylor C, Dávila Saldaña BJ, Keller MD, Seroogy CM, Desantes KB, Petrovic A, Leiding JW, Shyr DC, Decaluwe H, Teira P, Gillio AP, Knutsen A, Moore TB, Kletzel M, Craddock JA, Aquino V, Davis JH, Yu LC, Cuvelier GDE, Bednarski JJ, Goldman FD, Kang EM, Shereck E, Porteus MH, Connelly JA, Fleisher TA, Malech HL, Shearer WT, Szabolcs P, Thakar MS, Vander Lugt MT, Heimall J, Yin Z, Pulsipher MA, Pai SY, Kohn DB, Puck JM, Cowan MJ, O'Reilly R, Notarangelo LD: SCID genotype and 6-month post-transplant CD4 count predict survival and immune recovery: a PIDTC Retrospective Study. Blood, 2018; 132(17):1737-1749.

      Complete list of publications:

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