Marisa Tucci , M.D.
    Marisa Tucci
    Research Axis
    Infectious Diseases and Acute Care Axis
    Research Theme
    Critical care, trauma and transfusions
    CHUSJ - Centre de Recherche

    514-345-4931, ext. 3261

    514 345-7731


    • Full Clinical Professor, Department of Pediatrics, University of Montreal and CHU Sainte-Justine, 2015


    • Fellowship, Basic Sciences, Lawson Research Institute, University of Western Ontario, 1995-1996
    • Fellowship, Basic Sciences, The Pulmonary Center, Boston University, 1992-1995
    • Fellowship, Pediatric Intensive Care, CHU Sainte-Justine, University of Montreal, 1990-1992
    • Residency in Pediatrics, CHU Sainte-Justine, University of Montreal, 1987-1991
    • MD, University of Montreal, 1982-1987

    Research Interests

    During her basic research training, Dr Marisa Tucci participated in numerous research projects that aimed to characterize the nature of a distinct group of stress proteins called hypoxia-associated proteins as well as  the study of nitric oxide (NO) and insulin-like growth factor I (IGF-I) and their role in lung injury and tissue repair.

    Since 2001, Dr Tucci’s research interests have focused mainly on topics related to applied clinical research. Dr Tucci has undertaken and participated in various studies in the field of transfusion medicine.  She has been involved in various facets of research to specifically study the impact of red blood cell (RBC) unit storage time on the clinical outcome of critically ill children. Her work in recent years has involved the realization of studies that provided the preliminary data required to undertake an RCT on this issue, in vitro studies to assess the biochemical and immunological effect of prolonged storage on RBC units, generation of survey data to assess transfusion practices in pediatric hospitals in Canada and the US, and prospective epidemiological studies on the use of RBCs, platelets and plasma in critically ill children She has also been involved in research assessing transfusion complications and is currently a co-investigator in projects assessing development of post-transfusion Epstein-Barr Virus infection in stem cell transplant recipients as well as a plasma transfusion practices. She has participated in several National Heart Lung and Blood Institute (NHLBI) workshops and conferences to discuss scientific issues and to ascertain priorities in pediatric transfusion medicine.  She is currently the principal investigator of a multicenter randomized international clinical trial, the Age of Blood in Children in Pediatric Intensive Care Units (ABC-PICU) study that is CIHR and NHLBI funded that aims to recruit 1538 critically ill children and whose main goal is to assess the impact of red blood cell storage time on their outcome.

    Research Topics

    • Transfusion
    • Pediatric critical care
    • Multiple organ dysfunction syndrome
    • Applied clinical research

    Awards and Distinctions

    She has written 58 papers in peer-reviewed journal, 14 chapters, and more than 100 abstracts, posters and free papers. She has given 17 invited lectures, including several outside Canada and has received more than $12 million from academic granting agencies in the last 10 years. 


    • Tucci M, Karam O. Plasma transfusion practices. 8th World Congress on Pediatric Intensive and Critical Care to be held in Toronto, Canada, June 4-8, 2016.
    • Tucci M, Red blood cell storage in critically ill children. Society for the Advancement of Blood Management (SABM). Orlando, Florida, Sept 26 2015
    • Tucci M, Red blood cell storage time and clinical impact in critically ill children. Critical Care Medicine Research Rounds, Hospital for Sick Children, Toronto, Sept 24 2014
    • Tucci M, Red blood cell storage time and clinical impact in critically ill children. Canadian Society for Transfusion Medicine, 2 mai 2014

    Selected Publications

    1. Karam O, Demaret P, Duhamel A, Shefler A, Spinella PC, Stanworth SJ, Tucci M, Leteurtre S for the PlasmaTV investigators. Performance of the Pediatric Logistic Organ Dysfunction 2 score in critically ill children requiring plasma transfusions. Ann. Intensive Care (2016) 6:98, DOI 10.1186/s13613-016-0197-6 [in press].
    2. Karam O, Demaret P, Duhamel A, Shefler A, Spinella PC, Tucci M., for the PlasmaTV Investigators. Factors influencing plasma transfusion practices in paediatric intensive care units around the world. Vox Sang 2017 (in press)
    3. Lin JC; Spinella PC; Fitzgerald JC; Tucci M; Bush JL; Nadkarni VM; Thoma, NJ; Weiss SL; for the Sepsis Prevalence, Outcomes, and Therapy Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators Network.New or Progressive Multiple Organ Dysfunction Syndrome in Pediatric Severe Sepsis: A Sepsis Phenotype With Higher Morbidity and Mortality. Pediatric Critical Care Medicine. January 2017 - Volume 18 - Issue 1 - p 8–16 doi: 10.1097/PCC.0000000000000978
    4. Camazine MN, Karam O, Colvin R, Leteurtre S, Demaret P, Stanworth S, Muszynski J, Tucci M, Spinella PC, for the PlasmaTV investigators and the Pediatric Critical Care Blood Research Network (Blood Net). Outcomes Related to the Use of Frozen Plasma or Pooled Solvent/Detergent Treated Plasma in Critically Ill Children. Pediatric Crit Care Med 2017 (accepted)
    5. Peters M, Argent A, Festa M, Leteurtre S, Piva J, Thompson A, Willson D, Tissieres P, Tucci M, Lacroix J. The Intensive Care Medicine clinical research agenda in Paediatrics. Intensive Care Med 2017;43: in press 2017 Mar 17. doi: 10.1007/s00134-017-4729-9. (Epub ahead of print) (impact factor: 10.125).

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