Researcher

    Florina Moldovan , M.D. , Ph.D.

    florina.moldovan@umontreal.ca
    Florina Moldovan
    Research Axis
    Musculoskeletal Diseases and Rehabilitation
    Research Theme
    Spinal deformities and musculoskeletal diseases
    Address
    CHUSJ - Centre de Recherche

    Phone
    514 345-4931 #5746

    Fax
    514 345-4801

    Title

    • Full Professor, Faculty of Dental Medicine, Department of Stomatology, University of Montreal, 2006
    • Researcher, CHU Sainte-Justine Research Center, 2004
    • Director, Laboratoire de biologie moléculaire orthopédique (LBMO)
    • Chair, Comité institutionnel de bonnes pratiques animales en recherche  (CIBPAR )
    • Member, Council of the Faculty of Dental Medicine

    Education

    • Postdoctoral Fellow, Faculty of Medicine, University of Montreal and Unité de recherche en arthrose, Hôpital Notre-Dame, Montréal, 1995-1998.
    • PhD in Biochemistry, Université René Descartes, Paris V, 1995.
    • MS in Biotechnology, Université Pierre et Marie Curie, Paris VI, 1991.
    • Certificate in Endocrinology and Metabolic Diseases, Université Pierre et Marie Curie, Paris VI, 1990.
    • MD, University of Belgrade, Yugoslavia, 1986.

    Research Interests

    • Cellular and molecular biology and signal transduction in joint tissues;
    • Molecular interactions existing between endothelins (ETs), metalloproteases (MMPs) and tissue inhibitors of MMPs.

    Research Program

    • Osteoarthritis: Role of endothelins (ET-1) in the metalloproteases MMP/TIMPs system in human arthritic tissues (supported by the Canadian Institutes of Health Research).
    • Scoliosis: Biological role of estrogen receptors ERalpha and ERbeta receptors on idiopathic scoliosis.
    • Osteosarcoma: Role of the existing interactions between endothelins and metalloproteases (MMP) in the malignancy of the human osteosarcoma.

    Awards and Distinctions

    • Grammer Award - European Spine Journal, 2014.
    • Laureate, Fundamental Research, Yves Cotrel Foundation - Institut de France, 2006, 2010, 2012, 2016.
    • Carroll A. Laurin Award, Fundamental Orthopaedic Research, Canadian Orthopaedic Foundation, 2004.
    • Junior 2 Research Scholar, Fonds de la recherche en santé du Québec, 2004.
    • Research Scholar, Canadian Institutes of Health Research, 2001.
    • Fellow in Bioclinical Research, Claude Bernard Association, France, 1995.

    Most Important Publications

    1. Functional variants of POC5 identified in patients with idiopathic scoliosisPatten SA, Margaritte-Jeannin P, Bernard JC, Alix E, Labalme A, Besson A, Girard SL, Fendri K, Fraisse N, Biot B, Poizat C, Campan-Fournier A, Abelin-Genevois K, Cunin V, Zaouter C, Liao M, Lamy R, Lesca G, Menassa R, Marcaillou C, Letexier M, Sanlaville D, Berard J, Rouleau GA, Clerget-Darpoux F, Drapeau P, Moldovan F, Edery P. Functional variants of POC5 identified in patients with idiopathic scoliosis. J Clin Invest. 2015 Mar 2;125(3):1124-8. doi: 10.1172/JCI77262. Epub 2015 Feb 2
    2. Microarray expression profiling identifies genes with altered expression in Adolescent Idiopathic Scoliosis - Fendri K, Patten S, Kaufman G, Zaouter C, Parent S, Grimard G, Edery P, Moldovan F. Microarray expression profiling identifies genes with altered expression in Adolescent Idiopathic Scoliosis. Eur Spine J 2013; 22(6): 1300-1311.
    3. Role of Chd7 in zebrafish: a model for CHARGE syndrome - Patten S, Jacobs-McDaniels NL, Zaouter C, Drapeau P, Albertson RC, Moldovan F. Role of Chd7 in zebrafish: a model for CHARGE syndrome. PLoS ONE 2012; 7(2): e31650.
    4. Inhibition of inducible nitric oxide synthase prevents lipid peroxidation in osteoarthritic chondrocytes - Bentz M, Zaouter C, Shi Q, Fahmi H, Moldovan F, Fernandes JC, Benderdour M. Inhibition of inducible nitric oxide synthase prevents lipid peroxidation in osteoarthritic chondrocytes. J Cell Biochem 2012; 113(7): 2256-2267.
    5. The metabolic basis of adolescent idiopathic scoliosis: 2011 report of the "metabolic" workgroup of the Fondation Yves Cotrel - Acaroglu E, Bobe R, Enouf J, Marcucio R, Moldovan F, Moreau A. The metabolic basis of adolescent idiopathic scoliosis: 2011 report of the "metabolic" workgroup of the Fondation Yves Cotrel. Eur Spine J 2012; 21(6): 1033-1042.
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Edited by Hoffmann Maude

Created on 9/18/2014
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