Mariane Bertagnolli
    Mariane Bertagnolli
    Research Axis
    Fetomaternal and Neonatal Pathologies

    514 345-4931 #6146

    514 345-4801

    Research Project Title

    Rôle de l'angiotensine-(1-7), peptide contre-régulateur de l'angiotensine II, dans la programmation développementale de l'hypertension artérielle et de la fonction cardiaque.

    University Program

    Biomedical Sciences


    Université de Montréal

    Research Interests

    It has been proposed that perinatal and early postnatal life can result in the programming of adult diseases. However, the mechanisms that elicit such alterations are not fully understood. Oxidative stress generated in different models of programming, through exposure to dietary manipulation or neonatal exposure to hyperoxic stress, appears as an important mechanism affecting adult cardiovascular function.

    Recently, it has been demonstrated in rats that neonatal O2 exposure leads to hypertension, vascular dysfunction and extracellular matrix changes later in life. Importantly, vascular structural changes and microvascular rarefaction precede elevation of blood pressure. However, it remains to be determined whether cardiac dysfunction and oxidative stress, changes in cardiac structure and fibrosis also prevail in these hypertensive animals.

    The classical axis of the renin-angiotensin system (RAS), ACE/Ang II/AT1 receptor, plays an important role in the establishment and maintenance of elevated blood pressure in neonatal and other models of developmental programming of hypertension. The new RAS axis, ACE2-Ang(1-7)-Mas receptor, is beginning to be viewed as the principal counter-regulatory mechanism for the classical AT1-mediated effects of Ang II. In this project, we hypothesize that an imbalance between AngII/Ang(1-7) production participates in the vascular and – postulated – cardiac dysfunction and enhanced oxidative stress associated with neonatal hyperoxic exposure.

    The proposed research should shed light on the mechanisms underlying major health issues: the impact of O2-related damage of prematurity on cardiovascular risks and the overall concept of developmental programming of hypertension and cardiac diseases. Many studies now indicate that prematurity is associated with vascular dysfunction and high blood pressure in childhood, but the impact of perinatal conditions on heart development and function is not well known in either experimental animal models or humans. Considering that 8% of the population is born prematurely and that survival has increased markedly over the last three decades, these studies are particularly relevant to the growing proportion of adults born prematurely and possibly at significant risk of cardiovascular diseases.

    Awards and Distinctions

    • Research Travel Award IASH 2009, AHA Council for High Blood Pressure, 2009.
    • Post-doctoral Fellowship, Programa Nacional de Cooperaçao Acadêmica, Brazil, 2009.
    • Amil Award - Supporting Research, Sociedade Brasileira de Hipertensão, XVI Congresso Brasileiro de Hipertensao, 2008.
    • Young Investigator Travel Award, AHA Council for High Blood Pressure Research, VII Vasoactive Peptide Symposium, 2008.
    • PhD Fellowship, Conselho Nacional de Pesquisa, Brazil, 2005-2008.
    • MSc Scholarship, Conselho Nacional de Pesquisa (Brazil), 2003-2004.

    Selected Publications

    • Korb A, Bonetti LV, da Silva SA, Marcuzzo S, Ilha J, Bertagnolli M, Partata WA, Faccione-Heuser MC. Effect of treadmill exercise on serotonin immunoreactivity in medullary raphe nuclei and spinal cord following sciatic nerve transaction in rats. Neurochemical Research 2009 Sep 23. [electronic publication]. DOI 10.1007/s11064-009-0066-x.
    • Bertagnolli M, Schenkel PC, Campos C, Mostarda C, Casarini DE, Belló-Klein A, Irigoyen MC, Rigatto K. Exercise training reduces sympathetic modulation on cardiovascular system and cardiac oxidative stress in spontaneously hypertensive rats. Am J Hypertens 2008 Nov;21(11):1188-93.
    • Campos C, Bertagnolli M, Evangelho J, Tusset C, Belló-Klein A, Irigoyen MC, Rigatto K. Baroreflex sensitivity and oxidative stress in the LDL receptor knockout mice. Exp Toxicol Pathol 2008 Aug;60(4-5):329-35.
    • Bertagnolli M, Campos C, Schenkel PC, de Oliveira VLL, De Angelis K, Bello- Klein A, Rigatto K, Irigoyen MC. Baroreflex sensitivity improvement is associated with decreased oxidative stress in trained spontaneously hypertensive rats. J Hypertens 2006 Dec;24(12):2437-43.
    • Irigoyen MC, Paulini J, Flores LJ, Fkues K, Bertagnolli M, Moreira ED, Consolim-Colombo F, Bello-Klein A, De Angelis K. Exercise training improves baroreflex sensitivity associated with oxidative stress reduction in ovariectomized rats. Hypertension 2005 Oct;46(4):998-1003.
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Edited by Hoffmann Maude

Created on 9/18/2014
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