Researcher

    Emile Levy , M.D. , Ph.D.

    emile.levy@recherche-ste-justine.qc.ca
    Emile Levy
    Research Axis
    Metabolic Health and Complex Diseases
    Research Theme
    Cardiometabolic and vascular health: genetic and environmental approaches
    Address
    CHUSJ - Centre de Recherche

    Phone
    514 345-4931 #7783

    Fax
    514 345-4999

    Title

    • Full Professor, Department of Nutrition, Faculty of Medicine, University of Montreal
    • Affiliated Professor, Department of Paediatrics, Faculty of Medicine, University of Montreal
    • Affiliated Professor, Department of Anatomy and Cellular Biology, Faculty of Medicine, University of Sherbrooke
    • Member of the Directorate of the Sainte-Justine University Hospital Research Center
    • Scientific Director, Gastroenterology, Hepatology and Nutrition Unit, CHU Sainte-Justine
    • Director, Lipidology, Metabolism and Nutrition Laboratory, CHU Sainte-Justine
    • Coordinator of the Nutrition and Health Axis of the Institut sur la Nutrition et les Aliments Fonctionnels (INAF – Laval University, Quebec City)
    • Founder Member and Scientific Vice President of the EPODE (Ensemble, Prévenons l’Obésité Des Enfants – Together, Let’s Prevent Childhood Obesity) International Network
    • Recipient of the J.A. DeSève Research Chair in Nutrition

    Education

    • Research Fellow in Paediatric Gastroenterology and Nutrition, CHU Sainte-Justine Research Center, Montreal, 1986
    • PhD in Clinical and Physiological Biochemistry, Faculty of Medicine, Hebrew University, Jerusalem, 1984
    • Complementary medical science training, Faculty of Medicine, Hebrew University, Jerusalem, 1983
    • MSc in Biochemistry and Medical Sciences, Faculty of Medicine, Hebrew University, Jerusalem, 1978
    • BSc in Biology, Hebrew University, Jerusalem, 1974

    Research Interests

    • Lipid transport and cardiovascular diseases.
    • Lipoprotein metabolism, hyperlipidemia and atherosclerosis.
    • Nutritional disorders (obesity, insulin resistance, type 2 diabetes, Crohn's disease, etc.) and their links to oxidative stress and essential fatty acids.
    • Ontogeny and regulation of intestinal lipoprotein secretions.
    • Molecular and cellular study of intestinal malabsorptions (inflammatory bowel disease, cystic fibrosis, abetalipoproteinemia, hypobetalipoproteinemia, chylomicron retention, etc.) and hepatic diseases.
    • Gene-environment interactions, nutrigenomics, nutrigenetics, behavioural disorders associated with essential fatty acids.

    Significant Contributions

    • We have shown the beneficial impact of omega-3 fatty acids on adverse effects of the metabolic syndrome and emphasized their influence on intestinal lipid transport, an effect which may limit postprandial dyslipemia and atherosclerosis (Diabetologia 2006;49:1937-45).
    • We highlighted the active contribution of the intestine to hyperlipidemia characteristic of type 2 diabetes (Diabetes 2003;52:2539-2545).
    • We discovered the defective gene responsible for chylomicron retention disease and other malabsorption disorders (Nat Genet 2003;34(1):29-31).
    • The assembly of triglyceride-rich lipoproteins involves a complex process thought to occur exclusively in the endoplasmic reticulum. We were able to show that the Golgi apparatus actively participates in lipoprotein elaboration by involving key players, such as the microsomal triglyceride transfer protein (J Biol Chem 2002;277:16470-16477).
    • We demonstrated the impact of the intestinal fatty acid binding protein polymorphism (I-FABP) on intracellular lipid metabolism and transport, as well as on postprandial lipidemia in insulin resistance and type 2 diabetes (JBC 2001;276:39679-39684).

    Career Summary

    Dr Emile Levy is a Full Professor in the Department of Nutrition at the University of Montreal. He was the Director of the CHU Sainte-Justine Research Center from May 1996 to January 2006. He is now the Research Director of the Gastroenterology, Hepatology and Nutrition Unit at the CHU Sainte-Justine, where he heads an important research team, and the Director of the Lipidology, Metabolism and Nutrition Laboratory. In 2006, he was awarded the J.A. DeSève Research Chair in Nutrition.

    His studies undertaken over the past 25 years have considerably advanced our understanding of digestion, lipid absorption and metabolism, as well as their related diseases, including intestinal malabsorption, development disorders, primary and secondary hyperlipidemia, atherosclerosis, malnutrition, obesity, type 2 diabetes as well as inflammatory bowel disease. In addition, Dr Levy conducts research on infant development using nutrigenomic and proteomic approaches.

    Awards and Distinctions

    • Appointment to the Canadian Academy of Health Sciences, 2011
    • Appointment to the National Academy of Medicine in France, 2009
    • Scientific Mentor Award, Club de recherches cliniques du Québec, 2009
    • Career Research Award, Foundation of Stars, 2008
    • J.A. DeSève Research Chair in Nutrition, 2006
    • Award from the Société québécoise de lipidologie, métabolisme et nutrition, 2005
    • Award from the European Society for Biological Sciences, Tel Aviv, Israel, 2001
    • National Researcher Award, Fonds de la recherche en santé du Québec (FRSQ), 2000-2005
    • Senior 2 Research Scholar, FRSQ, 1998-2000
    • Senior 1 Research Scholar, FRSQ, 1994-1997
    • Junior 2 Research Scholar, FRSQ, 1992-1994
    • Borden Award in Nutrition, Canadian Society for Nutritional Sciences, 1991
    • Young Investigator Award for Excellence in Pediatric Research, Conseil des clubs sociaux du Québec, 1990
    • Junior 1 Research Scholar, FRSQ, 1988-1991
    • Research Fellowship Award, FRSQ, 1986-1987
    • Fellowship Award, Canadian Cystic Fibrosis Foundation, 1986-1987
    • Research Fellowship, Rothschild Foundation, Jerusalem, 1984-1986
    • Second Milan International Meeting Award, 1984
    • Honorific Scholarship, Hebrew University, Jerusalem, 1980-1984
    • Honorific Award, European Gastroenterology Association, London, 1978
    • Honorific Scholarship, Hebrew University, Jerusalem, 1976-1978
About this page
Edited by Hoffmann Maude

Created on 9/18/2014
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