Researcher

    Valérie Abadie , Ph.D.

    valerie.abadie@umontreal.ca
    Valérie Abadie
    Research Axis
    Viral and Immune Disorders and Cancers
    Research Theme
    Inflammatory and immune diseases: pathophysiological mechanisms and therapeutic approaches
    Address
    CHUSJ - Centre de Recherche

    Phone
    514 345-4931 #5201

    Title

    Assistant Professor, Department of microbiology and immunology, University of Montreal

    Education

    • Post-doctoral training in Mucosal Immunology, Department of Medicine, University of Chicago, 2008-2011
    • Post-doctoral training in Immunology, INSERM U945, Paris, 2006-2008
    • Ph.D. in Microbiology-Virology, Université Paris VII, Paris, 2001-2005

    Research Interests

    • Impact of viral enteric infections on humoral immune responses in the intestinal mucosa
    • Role of the pro-inflammatory cytokine IL-15 in the induction of humoral responses
    • Celiac disease pathogenesis
    • Impact of inflammation on the efficiency of oral vaccines

    Career Summary

    Valérie Abadie received her undergraduate degrees in cellular biology and physiology at Paul Sabatier University, Toulouse, France. She next completed a Master degree in microbiology at Paris V-Necker Enfants malades and obtained her Ph.D. in Microbiology-Virology from the University of Paris VII in 2005. Valérie Abadie's research focuses on the study of the regulation of mucosal immune responses. She is particularly interested in studying the mechanisms underlying humoral responses in the intestinal mucosa, and how these immune responses can be deregulated in an inflammatory context.

    Characterization of mucosal humoral responses to dsRNA viruses
    Double-stranded RNA (dsRNA) viruses are the most common cause of life-threatening gastroenteritis in children and infants worldwide. In addition, dsRNA viruses are also thought to trigger autoimmune diseases. Many attempts have been made to design efficient mucosal vaccines to prevent deadly diarrhea in children of developing countries, yet their success has been very limited. The failure of such vaccines can be partly explained by our very limited knowledge about the mechanisms underlying the induction of humoral immunity in the gastrointestinal mucosa following oral antigen administration. Mucosal antibody responses play a major role in mediating homeostasis with the intestinal microbiota as well as protection against invading pathogens. Using reovirus as a model, Dr Abadie's lab aims to characterize the nature of the antibody response induced in the intestinal mucosa in response to a dsRNA virus oral infection and to identify the pathways involved in the establishment of humoral immunity.

    Impact of IL-15 on mucosal humoral responses
    IL-15 is a pro-inflammatory cytokine involved in many biological activities including the development, proliferation, survival and differentiation of multiple cells from both innate and adaptive immune systems. Abnormalities of IL-15 expression, and in particular its over-expression, have been reported in a variety of inflammatory and autoimmune disorders, yet its contribution to the dysregulation of mucosal B cell responses has not been studied. We are interested in expanding our current knowledge of the inflammatory role of IL-15 in modulating intestinal regulatory responses and more specifically in the regulation/dysregulation of humoral adaptive immune responses generated in germinal centers. By using a combination of in vivo experiments using IL-15 transgenic mice and in vitro immunological assays, we will test the hypothesis that IL-15 may affect the regulation of germinal center responses and consequently B cell antibody production in the gut. This project will extend our understanding of the molecular mechanisms by which mucosal B cell responses can be dysregulated.

    Celiac disease pathogenesis
    We are working on deciphering the immune mechanisms involved in the development of villous atrophy in celiac disease.

    Awards and Distinctions

    • Young IBD Investigator Award in the Research Fellowship Award category from the Crohn's & Colitis Foundation of America (CCFA), 2011
    • Research fellowship award, Crohn's & Colitis Foundation of America (CCFA), 2010-2011
    • Post-Doctoral fellowship, Fondation pour la Recherche Médicale (FRM), 2006-2007
    • Doctoral fellowship Pasteur-Weizmann, 2005
    • Doctoral fellowship, Agence Nationale de Recherche sur le Sida (ANRS) from, 2002-2004

    Presentations

    Update on the Immunology of Celiac Disease: Implications for Diagnosis and Treatment; Claude Roy symposium on Nutrition and Child Health at the Canadian Nutrition Society Meeting 2012, Vancouver, Canada, 2012.

    Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens; 14TH International Coeliac Disease Symposium 2011, Oslo, Norway, 2011.

    Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens; Keystone Symposium 'Mucosal Biology: A fine balance between tolerance and immunity', Vancouver, Canada, 2011.

About this page
Edited by Hoffmann Maude

Created on 9/18/2014
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