Researcher

    Hugo Soudeyns , Ph.D.

    hugo.soudeyns@recherche-ste-justine.qc.ca
    Hugo Soudeyns
    Research Axis
    Viral and Immune Disorders and Cancers
    Research Theme
    Infection and immunity
    Address
    CHUSJ - Centre de Recherche

    Phone
    514-345-4931, ext. 3907

    Fax
    514 345-4794

    Title

    • Head, Research Axis, Infectious Diseases and Acute Care, CHU Sainte-Justine Research Center 
    • Full Professor, Department of Microbiology, Infectiology & Immunology, Université de Montréal.
    • Full Professor, Department of Pediatrics, Université de Montréal.
    • Chair, Department of Microbiology, Infectiology & Immunology, Université de Montréal.

    Education

    • Posdoctorate, AIDS Immunopathology, Centre hospitalier universitaire Vaudois, 1999.
    • PhD, Microbiology & Immunology, McGill University, 1997.

    Research Interests

    Hugo Soudeyns trained in microbiology and immunology. He has been mostly active in three main areas of HIV/AIDS research. In January 2000, Dr Soudeyns opened a research unit devoted to the study of viral immunopathology at Centre de recherche du CHU Sainte-Justine. In collaboration with the Centre maternel et infantile sur le sida (CHU Sainte-Justine), the work of Dr. Soudeyns has led to the identification of important differences in cell-mediated immunity between adults and children, and contributed to the understanding of the pathogenesis of pediatric HIV infection. At the present time, the primary research interests of Dr. Soudeyns are mainly focused on mother-to-child transmission of viral diseases, notably HIV-AIDS and hepatitis C. His team is pursuing work on three main subjects.

    Study of the pathogenesis of hepatitis C in pregnancy and childhood

    Hepatitis C is a chronic disease of the liver that is caused by a virus called hepatitis C virus (HCV). This disease, which affects more than 250,000 Canadians, can lead to cirrhosis, hepatic dysfunction, and, in certain cases, necessitates the patient to undergo liver transplantation. Hepatitis C tends to worsen after pregnancy in infected women. In addition, HCV can be transmitted to the child during pregnancy and childbirth. The work of Dr. Soudeyns and his team are aimed at acquiring a better understanding of the mechanisms that lead to the worsening of hepatitis C, at better defining the role of the immune system in the control of this disease, and at identifying the precise manner (where, when and how) by which HCV is passed from the mother to the child. The ultimate goal of this research is to improve the clinical care of women suffering from hepatitis C and to prevent mother-to-child transmission of HCV. As there are new and efficient drugs that now allow HCV infection to be cured, the role that these treatments will play in the management of hepatitis C in women and children must be better defined.

    Studies of long-term remission of HIV infection in children and adolescents

    Like HCV, human immunodeficiency virus (HIV), also known as the AIDS virus, can be transmitted from mother to child during pregnancy, childbirth, and breastfeeding. For many years, drugs have been available that can prevent mother-to-child transmission of HIV in the large majority of cases when administered to the pregnant woman and her newborn. However, there are some children who nonetheless become infected. In these children, it is thought that treatment with powerful drug combinations in the first hours of life could allow a better control of HIV Infection in the long term. This is what apparently happened in the case of the ''Mississippi Baby'', a young girl who was able to keep HIV in check for over 2 years, event after her treatment was interrupted. Such long-term remissions were also observed in a minority of teenagers, who are also capable of controlling HIV in absence of medication. Understanding of the mechanism(s) whereby this kind of durable remission can take place could open the door to the development of novel practices in the management of HIV infection in our young patients. In the context of the EPIC4 Study, Dr. Soudeyns, his team and his collaborators in Canada and the United States are following multiple leads, including that of the existence of so-called ''non-conventional'' immune responses that could play a key role in this process.

    Study of the reconstitution of antiviral immunity in transplanted children

    Hematopoietic stem cell transplantation is commonly used to reconstitute the blood and immune systems in leukemic children who have been treated with chemotherapy and radiation therapy. These stem cells can originate from the bone marrow of a compatible or related donor, or can be sourced from umbilical cord blood (UCB). After receiving such a transplantation, leukemic children face multiple, potentially dangerous clinical complications: graft rejection (engraftment failure), graft-versus-host disease, leukemic relapse, and opportunistic infections, often times caused by viruses that are innocuous for most healthy people. This susceptibility to infections is caused in part by delayed reconstitution of the immune system in the young graft recipient, reconstitution that sometimes takes many months. Dr. Soudeyns and his team intend to understand the mechanisms that delay immune reconstitution and to identify at an early stage the children who are most at risk to develop infectious complications and/or leukemic relapse, with the goal of putting new tools and modes of intervention in the hands of medical oncologists and transplantation specialists.

    Research Topics

    • Immunology.
    • HIV-AIDS.
    • Hepatitis C.
    • Virology.
    • Cell-mediated immune responses.
    • Immune reconstitution.

    Awards and Distinctions

    • Justine Prize (exceptional contribution), CHU Sainte-Justine, Montreal, Quebec, 2011.
    • PhD thesis featured on the Dean's Honor List, McGill University, 1997.
    • New Investigator Award (Basic Science), Canadian Association for HIV Research, 1996.

    Presentations

    • Où en sommes-nous en ce qui concerne la « guérison » du VIH chez les enfants et les adolescents? Journées québécoises VIH 2017, Montréal, Canada, 03/2017. 
    • EPIC4: overview and update from the « other » CIHR HIV cure study. Réunion annuelle du Consortium canadien de recherche sur la guérison du VIH (CanCURE), Montréal, Canada, 11/2016.
    • Le VIH et le VHC en grossesse et chez l’enfant: mieux comprendre, mieux traiter, mieux… guérir? Université du Québec à Trois-Rivières (UQTR), Trois-Rivières, Canada, 11/2015.
    • Infections virales chroniques chez l’enfant: comprendre, traiter, guérir? Soirée scientifique « Grandir à l’adolescence en santé: Innovations du Centre de recherche du CHU Sainte-Justine », Montréal, Canada, 10/2015.
    • Unité d’immunopathologie virale: recherche fondamentale et translationnelle, 2015-2016. Retraite scientifique et Congrès des étudiants du Centre de recherche du CHU Sainte-Justine 2015, Saint-Sauveur, Canada, 05/2015.
    • Virologic, immunologic and clinical aspects of hepatitis C virus infection during pregnancy and childhood. 1st Symposium on Molecular Aspects of Virology (MAV 2014). Different viruses, different hosts, one challenge: disease control. Mexico, Mexique. State-of-the-art lecture, 10/2014.
    • Transmission mère-enfant du virus de l'hépatite C: pathogenèse et études moléculaires. Séminaires de recherche du Centre de recherche du CHUM (CR-CHUM), Montréal, Canada, 05/2014.
    • Pregnancy, childbirth and childhood: genesis and evolution of antiviral immune responses. Division of Health Sciences Research Seminar, University of Otago, Dunedin, Nouvelle-Zélande, 04/2014.

    Most Important Publications

    • Calzas C, Taillardet M, Salem Fourati I, Roy D, Gottschalk M, Soudeyns H, Defrance T, Segura M. 2017. Evaluation of the immunomodulatory properties of Streptococcus suis and group B Streptococcus capsular polysaccharides on the humoral response. Pathogens 6(2): E16.
    • Abdel-Hakeem M, Boisvert M, Bruneau J, Soudeyns H, Shoukry N. 2017. Selective expansion of high functional avidity memory CD8 T cell clonotypes during hepatitis C virus reinfection and clearance. PLoS Pathogens 13(2): e1006191.
    • Wacleche VS, Goulet JP, Gosselin A, Monteiro P, Soudeyns H, Fromentin R, Jenabian MA, Vartanian S, Deeks SG, Chomont N, Routy JP, Ancuta P. 2016. New insights into the heterogeneity of Th17 subsets contributing to HIV-1 persistence during antiretroviral therapy. Retrovirology 13(1): 59.
    • Kakkar F, Van der Linden D, Valois S, Maurice F, Onnorouille M, Lapointe N, Soudeyns H, Lamarre V. 2016. Health outcomes and the transition experience of HIV-infected adolescents after transfer to adult care in Québec, Canada. BMC Pediatr 16: 109.
    • Soudeyns H. 2015. Understanding risk factors for incident maternal HIV-1 infection. AIDS 29: 2053-2054.
About this page
Edited by Hoffmann Maude

Created on 9/18/2014
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