Martin Frasch , M.D. , Ph.D.
    Martin Frasch
    Research Axis
    Fetomaternal and Neonatal Pathologies
    Research Theme
    Fetal development and prematurity

    514 345-4931 #4048



    • Assistant Research Professor, Departments of Obstetrics-Gynecology and Neurosciences, Faculty of Medicine, University of Montréal.
    • Member, Centre de recherche en reproduction animale (CRRA), Faculty of Veterinary Medicine, University of Montreal.
    • Adjunct Scientist, Lawson Health Research Institute, London, Ontario.
    • Adjunct Member to the Graduate Program in Mathematics & Statistics, York University, Toronto, Canada


    Postdoctoral Fellow

    • Department of Obstetrics and Gynaecology, Children Health Research Institute, Lawson Health Research Institute, University of Western Ontario, Canada, 2009.
    • Research Topics and Interests
      • Effects of chronic hypoxia without progressive acidemia as might be seen in the human fetus antenatally on brain development and inflammatory response;
      • Effects of acute hypoxia with progressive acidemia as might be seen during labor on fetal electrical brain activity (ECoG, EEG) and systemic and brain inflammatory responses;
      • Developmental changes in fetal electrocortical activity (sleep states) due to chronic hypoxia in the last pregnancy trimester.

    Residency and Research

    • Department of Neurology, School of Medicine, Friedrich Schiller University, Jena, Germany. Research on fetal asphyxia and programming of adult diseases (Principal Investigator: Matthias Schwab, Prof. Dr. med. habil.), 2006.
    • Research Topics and Interests
      • Acute and chronic effects of hypoxia with and without acute or long-term effects of betamethasone administration on fetal heart rate variability as well as fetal electrical spontaneous (ECoG) and evoked (SEP, AEP) brain activity and cerebral blood flow;
      • Acute and subacute alterations in autonomic nervous system activity in adult patients with ischemic stroke.

    Doctorate in Neurosciences (summa cum laude)

    • Institute for Pathophysiology (School of Medicine), Friedrich Schiller University, Jena, Germany. Advisor: Prof. Ulrich Zwiener, Dr. med. habil., PhD. Thesis: Investigating complex coordination of neurovegetative and brain electrical activities in sleep and anesthesia using nonlinear signal analysis. Awarded October 4, 2004.
    • Research Topics and Interests
      • By studying the coupling between heart rate variability and respiratory movements, I was able to retrospectively discriminate human neonates at low and normal risk for adverse outcomes during the first year of life. I also characterized information flow in reticulo-thalamo-cortical communication in an animal model of propofol sedation using analysis of linear and complexity properties of cortical and thalamic electrical activity.

    Doctor of Medicine

    • Friedrich Schiller University, Jena, Germany, 2001.

    Research Interests

    • Antenatal brain development under normal and stress conditions. Focus on autonomic nervous system responses to inflammation (fetal neuroimmunology). Fetal cholinergic anti-inflammatory pathway;
    • Monitoring fetal and neonatal well-being using computer-aided EEG and ECG (HRV) analyses;
    • Postnatal consequences of prenatal stress (fetal programming of adult diseases). I am also interested in how methods derived from the theory of nonlinear dynamics can be used to estimate neuronal complexity and to improve prediction of the physiological and pathophysiological behavior mentioned above.

    Awards and Distinctions


    • Post-doctoral Scholarship, Strategic Training Initiative in Research in the Reproductive Health Sciences, Canadian Institutes of Health Research (CIHR)/Association of Professors of Obstetrics and Gynaecology of Canada, 2008-2009.
    • E-Fellows Award, industry-sponsored mentorship program awarded for academic excellence and extracurricular activities (, 1999-2004.
    • Scholarship Award, Friedrich-Naumann Foundation, for academic excellence and social engagement, 1997-2001.

    Prizes (selected)

    • Travel Award, Child Health Research Institute, Ontario, 2010.
    • SGI/Wyeth President’s Presenter Award, 2009.
    • Travel Award, CIHR Institute of Human Development, Child and Youth, 2009.
    • Travel Award, Child Health Research Institute, Ontario, 2007-2008.
    • Travel Award, CIHR Institute of Human Development, Child and Youth, 2007.
    • Young Investigator Travel Award, National Institutes of Health, USA, 2007.
    • "The Michael Smith Foundation for Health Research (MSFHR) Young Investigator Award, 2011"


    • Modeling fetal ECOG/EEG during labour. 5th Montreal Problem Solving Workshop. A CRM-Mprime Event. Université de Montréal. August 19-23, 2013.
    • Smallest Patients – big data. Challenges of fetal monitoring. University of Ontario Institute of Technology. Oshawa, ON. June 26, 2013.
    • Mathematical approach to integrative physiology of the developing brain. February 25, 2013. College of Mathematical Sciences, Nankai University, Tianjin, China.
    • Fetal neuroinflammation and complex signal bioinformatics: a bench-to-bed journey on a sheep. November 23, 2012. Dept. of Physiology, Université de Montréal.
    • Online detection of physiological fetal distress pattern during birth. MBI BioSciences Problem-Solving Workshop (PSW@MBI), July 16-20, 2012. Columbus, OH, USA.
    • La réponse fœtale inflammatoire cérébrale: les études du modèle chroniquement instrumentés de brebis. Journée de la recherche Mère-Enfant de Sherbrooke, 7 juin, 2012. Sherbrooke, QC, Canada.
    • Mathematical properties of fetal heart rate variability and electroencephalogram: a journey from complex signal bioinformatics to bedside fetal health monitoring. Centre for Mathematical Medicine. Fields Institute. University of Toronto. March 16, 2012. Toronto, ON, Canada.
    • Mechanisms and manipulation of fetal neuroimmune responses to inflammation. NeuroDevNet Brain Development Conference 2011. June 19-21, Vancouver, BC, Canada.
    • Mécanismes et manipulation des réponses neuroimmunitaires foetales à l’infection. Colloque #117 La cascade inflammatoire chez le prématuré : un continuum de la mère à l’enfant. 79e Congrès de l’ACFAS. May 9-13, 2011. Université de Sherbrooke. Canada.
About this page
Edited by Hoffmann Maude

Created on 9/18/2014
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