Richard L. Momparler , Ph.D.
    Richard L. Momparler
    Research Axis
    Immune Disorders and Cancers
    Research Theme
    Cancer: genetic and molecular mechanisms, and new therapies
    CHUSJ - Centre de Recherche

    514 345-4931 #6140

    514 345-4801


    • Professor, Department of Pharmacology, University of Montreal, 1985.
    • Researcher, CHU Sainte-Justine Research Center, 1977.


    • Postdoctoral Fellow, Biochemistry, International Laboratory Genetics & Biophysics, Naples, Italy, 1966.
    • Postdoctoral Fellow, Pharmacology, Yale University, 1965.
    • PhD, Pharmacology, University of Vermont, 1964.
    • BSc, Biology, Michigan State University, 1957.

    Research Interests

    Richard Momparler’s main research interests relate to the evaluation of various experimental agents in cancer chemotherapy. Richard Momparler was the first to reveal Ara-C’s mechanism of action as a chain terminator. He was also the first to propose the use of high-dose Ara-C in acute leukemia therapy. Through investigations using mouse models he discovered that 5-azadeoxycytidine (5-aza) was a more potent antileukemic agent than Ara-C. In collaboration with his team and hematologists working at the CHU Sainte-Justine, he was the first to conduct a clinical trial on 5-aza in children suffering from leukemia and demonstrate that 5-aza is an active agent. During cancer development many tumor suppressor genes are inactivated by aberrant DNA methylation. Richard Momparler’s laboratory was the first to demonstrate that methylation of retinoic acid receptor beta (RARb) inactivated tumor suppressor genes in colon and breast cancer in humans.

    In collaboration with Joseph Ayoub at Notre-Dame Hospital, his team conducted a clinical trial on the effect of 5-aza in patients with advanced lung cancer and demonstrated that it is an active antitumor agent. More recently, Richard Momparler’s team has investigated other histone deacetylation inhibitors for use in combination with 5-aza. Current data suggest that these interesting inhibitors enhance the antineoplastic activity of 5-aza and that the use of 5-aza in combination with these agents would be effective in future clinical trials conducted on cancer patients.

    Career Summary

    • Associate Professor, Department of Pharmacology, University of Montreal, 1977-1984.
    • Associate Professor, Department of Pharmacology, University of Southern California, Los Angeles, 1972-1976.
    • Assistant Professor, Department of Biochemistry, McGill University, 1967-1971
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Edited by Hoffmann Maude

Created on 9/18/2014
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