Research Axis
Musculoskeletal Health, Rehabilitation and Medical Technologies Axis
Research Theme
Study and more efficient approaches for spinal deformities and musculoskeletal diseases
Address
CHUSJ - Centre de Recherche
Phone
514 345-4931 6200
My research program is primarily focused on the study of in situ vitamin D absorption and metabolism in organs that are especially affected by cystic fibrosis (CF) such as the intestine and pancreas. The work is being carried out in parallel with a number of cohort studies aimed at characterizing the vitamin D nutritional status of populations potentially at risk of deficiency and studying the association between this condition of insufficiency and certain parameters of clinical interest.
More specifically, the objectives being pursued are the following:
- A study of the impact of manifestations associated with CF such as the absence of CFTR, chronic inflammation, oxidative stress and essential fatty acid deficiency on vitamin D absorption and metabolism by intestinal and endocrine pancreatic cells. An understanding of the mechanisms that surround vitamin D absorption and a study of the influence of genetic inheritance.
- A study of the impact of insufficient nutritional status and vitamin D deficient status in CF individuals on the antioxidant and detoxifying functions of intestinal cells and on the secretory functions of endocrine pancreatic cells.
The higher life expectancy enjoyed by CF patients has led to an increase in the number of pregnancies in this population. CF women must therefore face the combined (patho)physiological effects of CF and pregnancy. I am also interested in the study of the overall vitamin D nutritional status of CF women during pregnancy and the postnatal period.