Researcher

    Daniel Sinnett , Ph.D.

    daniel.sinnett@umontreal.ca
    Daniel Sinnett
    Research Axis
    Viral and Immune Disorders and Cancers
    Research Theme
    Cancer: genetic and molecular mechanisms, and new therapies
    Address
    CHUSJ - Centre de Recherche

    Phone
    514-345-4931, ext. 2990

    Fax
    514-345-4731

    Title

    • Full Time Professor, Department of Pediatrics, University of Montreal
    • Accredited Professor, Department of Biochemistry and Molecular Medicine, University of Montreal
    • Scientific, Robert Cedergren Centre, Bioinformatics and Genomics Research Centre, University of Montreal
    • Chief, Research Axis, Viral and Immune Disorders and Cancers
    • Co-chief, Pole of Excellence, Immune Diseases and Cancer
    • Director, Newtwork of Applied Genetic Medicine, Fonds de recherche du Québec - Santé (FRQS)

    Education

    • Postdoctoral Fellow, Harvard Medical School, Children’s Hospital, Boston, USA, 1991-1994
    • Ph.D., Biochemistry, University of Montreal, 1987-1991

    Research Interests

    The Role of the transcription factor ETV6 in Childhood Leukemia

    Oncogenesis is a multi-stage process involving genetic alterations in a number of oncogenes and tumour suppressor genes. Over the years, we and others have identified and characterized allelic losses in leukemic cells from childhood Acute lymphoblastic leukemia (ALL) patients. Creation of the ETV6-AML1 fusion gene and complete inactivation of ETV6 following a secondary deletion event, is a situation that is unique to childhood ALL. However the t(12;21) translocation is not sufficient to trigger leukemogenesis, therefore it is possible that loss of the non-translocated ETV6 allele could represent a key initiating event in the leukemic process, probably through disruption of the downstream regulatory network. ETV6 is a member of the ETS family of transcription factors, and functions as a transcriptional repressor during normal hematopoiesis. Our work has focused on dissecting the role of ETV6 and of the underlying mechanisms leading to leukemogenesis. Given that we know little about the genes targeted by this transcriptional repressor, the main goal of this project is to build the gene regulatory network associated with expression of ETV6. We have proposed a global approach in which we integrate data generated through DNA, RNA and protein studies to identify proteins that interact with ETV6 and genes that are targeted by ETV6 to further elucidate the mechanism through which disruption of this tumour-suppressor promotes the leukemic process. These findings will then be used to develop more appropriate and more efficient diagnostic and treatment tools for childhood ALL patients.

    Genetic and genomic determinants of childhood leukemia

    Acute lymphoblastic leukemia (ALL) is the most frequent cancer and the leading cause of death due to disease among children aged 18 or younger. Despite what is known about the leukemic process, there remains much to be learned about the molecular causes of this disease. Few studies have thoroughly investigated the role of inherited genetic variation in influencing a child's risk of ALL. We and others have shown that childhood ALL might originate through the collective contribution of DNA variants in genes controlling the efficiency of carcinogen metabolism, the capacity of maintaining DNA integrity and the response to oxidative stress. More recently, two GWAS have provided the first genome-wide glimpse into the role of inherited alleles in ALL pathogenesis and identified common germline variants associated with the pathogenesis and heterogeneity of pediatric ALL. Still few bona fide genetic risk factors for ALL have been identified and therefore the genetic contribution to childhood ALL remains largely unexplained. It is likely that this complex disease is caused by a combination of both common and rare variants. In fact, a more realistic disease model is that functional variants involved in childhood ALL onset have a wide spectrum of allele frequencies that range from common to not-so-common to rare and that the landscape of genetic variation contributing to ALL includes structural variation, epigenetic changes, and even parentally-mediated genetic effects. The advent of next-generation sequencing and sophisticated bioinformatic tools, combined with the availability of unique well-characterized cohorts of ALL patients is providing us with unprecedented views of the genetic landscape of childhood ALL, allowing us to simultaneously detect common and rare inherited (germline) genetic changes as well as leukemia-specific (somatic) mutations in childhood ALL genomes. Our main goal is to identify the full complement of genetic and epigenetic variation in childhood ALL genomes. Using cutting-edge technologies, we are performing deep-resequencing of over 800 genomes from matched normal-tumour patient samples, as well as mothers and fathers of leukemia patients. In parallele we are also generating transcriptomic data (RNA-seq), genome-wide genotyping data, as well as array-based methylation profiling, in order to build a comprehensive catalogue of genomic (sequence and structural) as well as epigenomic variants involved in childhood ALL. In response to the important challenge of integrating these various sources of information, and identifying true causal events involved in driving leukemogenesis, we are developing new bioinformatics tools. These findings will ultimately lead to development of powerful research and clinical tools that could improve detection, diagnosis and treatment of childhood leukemia.

    Investigating the Genetic determinants of Long Term Side Effects of Treatment in Childhood Leukemia Survivors

    The primary factor that led to advances in childhood ALL survival is the introduction of multi-agent treatment regimens based on predicted risk of relapse using clinical- and laboratory-based outcome variables (risk-adapted therapy). However, there is a price to pay for this therapeutic success. Although 85% of ALL cases are cured with modern therapy, the exposure to chemotherapeutic agents and/or irradiation during a vulnerable period of development has been associated with high frequency of late-occurring health problems in more than two-thirds of the survivors. There is substantial variability regarding the occurrence and severity of the therapy-related morbidities in ALL survivors and importantly, the underlying causes of these long-term effects remain unclear. Early-detection biomarkers which would identify population at risk are currently lacking. We gathered a multidisciplinary team of clinical and basic scientists to comprehensively investigate and identify biomarkers of the most common therapy-related late effects in childhood ALL survivors, including neurocognitive effects, metabolic syndrome, cardiotoxicity and bone morbidity. To better understand the mechanisms through which these adverse long-term effects might arise in childhood ALL survivors we propose a study to identify the genetic variations in childhood ALL patients and a set of biologically and clinically relevant biomarkers on long-term treatment effects. We also want to assess the impact of candidate genetic and biological biomarkers on long-term treatment in childhood ALL survivors. These findings will lead to the development of new strategies and clinical tools that will prevent and/or reduce the occurrence of late-onset treatment related toxicities, and ultimately improve detection, diagnosis and treatment of childhood leukemia.

    Awards and Distinctions

    • National Scientist, Fonds de la recherche en santé du Québec (FRSQ), 2006-2011
    • Lauréat du programme de reconnaissance, Prix recherche, CHU Sainte-Justine, 2009
    • Senior Scientist Scholar, FRSQ, 2002-2006
    • Prix d’accomplissement, Recherche Biomédicale, Faculté de Médecine/ Association des diplômés, Université de Montréal, 2005
    • Prix du jeune chercheur André Dupont, 2004
    • Prix Mérite du Conseil québécois de lutte contre le cancer, 2003
    • Chairholder, François-Karl Viau Research Chair in Pediatric, 2002
    • Junior 2 Scientist Scholar, FRSQ, 1998-2002
    • Prix d’Excellence, Fondation de la recherche sur les maladies infantiles, 1999
    • Junior 1 Scientist Scholar, FRSQ, 1994-1998
    • Postdoctoral Fellowship, Canadian Institutes of Health Research, 1991-1994

    Most Important Publications

    • B. Ge, D. K. Pokholok, E. Grundberg,  T. Kwan, L. Morcos, J. Le,  D.J. Verlaan, V. Koka, K.C.L. Lam, V. Gagné, J. Dias, R. Hoberman, A. Montpetit, M.M. Joly, E. J. Harvey, D. Sinnett, P. Beaulieu*, R. Hamon*, A. Graziani, K. Dewar, E. Harmsen, J. Majewski, A.K. Naumova,  M. Blanchette, H.H.H. Göring, K.L. Gunderson, T. Pastinen (2009). Global patterns of cis-variation in human cells revealed by high-density allelic expression analysis. Nature Genetics  Nov;41(11):1216-22.
    • Sherborne A, Hosking FJ, Prasad RB, Kumar R, Koehler R, Vijayakrishnan J, Papaemmanuil E, Bartram CR, Stanulla M, Schrappe M, Gast A, Sheridan E, Taylor M, Kinsey SE, Lightfoot T, Roman E, Irving JAE, Allan JM, Moorman AV, Harrison CJ, Tomlinson IP, Szalai C, Semsei AF, Erdelyi DJ, Krajinovic M, Sinnett D, Healy J, Neira AG, Hemminki K, Greaves M, Houlston RS (2010). Variation at 9p21.3 (CKN2A) influences childhood acute lymphoblastic leukemia risk. Nat Genet. Jun;42(6):492-4.
    • Busche S, Ge B, Vidal R, Spinella J-F, Saillour V, Richer C, Healy J, Chen S-H, Droit A, Sinnett D#, Pastinen T. (2013) Integration of high-resolution methylome and transcriptome analyses to dissect epigenomic changes in childhood acute lymphoblastic leukemia. Cancer Research, May 35(4) e157-162. #corresponding author.
    • Spinella J-F, Cassart P, Richer C, Saillour V, Ouimet M, Langlois S, St-Onge P, Sontag T, Healy J, Minden M, Sinnett D (2016) The genomic characterization of pediatric T-cell acute lymphoblastic leukemia reveals novel recurrent driver mutations.  Oncotarget 2016 Sep 1. doi: 10.18632/oncotarget.11796
    • Marcoux S, Drouin S, Laverdière C, Alos N, Andelfinger GU, Bertout L, Curnier D, Friedrich MG, Kritikou EA, Levy E, Lippé S, Marcil V, Raboisson M-J, Rauch F, Robaey P, Séguin C, Sultan S, Krajinovic M, Sinnett D.  (2016)The PETALE Study: Late Adverse Effects and Biomarkers in Childhood Acute Lymphoblastic Leukemia Survivors.  Pediatric Blood & Cancer Dec 4. doi: 10.1002/pbc.26361  (PETALE-CIHR team leader)

Publications

Hoxa9 collaborates with E2A-PBX1 in mouse B cell leukemia in association with Flt3 activation and decrease of B cell gene expression - Hassawi M, Shestakova EA, Fournier M, Lebert-Ghali CÉ, Vaisson G, Frison H, Sinnett D, Vidal R, Thompson A, Bijl JJ. Hoxa9 collaborates with E2A-PBX1 in mouse B cell leukemia in association with Flt3 activation and decrease of B cell gene expression. Dev Dynamics 2014; 243(1): 145-158.

Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia - Nordlund J, Bäcklin CL, Wahlberg P, Busche S, Berglund EC, Eloranta ML, Flaegstad T, Forestier E, Frost BM, Harila-Saari A, Heyman M, Jónsson OG, Larsson R, Palle J, Rönnblom L, Schmiegelow K, Sinnett D, Söderhäll S, Pastinen T, Gustafsson MG, Lönnerholm G, Syvänen AC. Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia. Genome Biol 2014; 14(9): (sous presse).

Sar1b transgenic male mice are more susceptible to high-fat diet-induced obesity, insulin insensitivity and intestinal chylomicron overproduction - Levy E, Spahis S, Garofalo C, Marcil V, Montoudis A, Sinnett D, Sanchez R, Peretti N, Beaulieu J-F, Sané A. Sar1b transgenic male mice are more susceptible to high-fat diet-induced obesity, insulin insensitivity and intestinal chylomicron overproduction. J Nutr Biochem 2014; 25(5): 540-548.

Pharmacogenetic considerations for acute lymphoblastic leukemia therapies - Dulucq S, Laverdière C, Sinnett D, Krajinovic M. Pharmacogenetic considerations for acute lymphoblastic leukemia therapies. Expert Opin Drug Metab Toxicol 2014; 10(5): 699-719.

Impact of promoter polymorphisms in key regulators of the intrinsic apoptosis pathway in childhood acute lymphoblastic leukemia outcome - Sanchez R, St-Cyr J, Lalonde ME, Healy J, Richer C, Gagné V, Laverdière C, Silverman LB, Sallan SE, Neuberg D, Kutok JL, Kritikou EA, Krajinovic M, Sinnett D. Impact of promoter polymorphisms in key regulators of the intrinsic apoptosis pathway in childhood acute lymphoblastic leukemia outcome. Haematologica 2013; (sous presse).

Rare allelic forms of PRDM9 associated with childhood leukemogenesis - Hussin J, Sinnett D, Casals F, Idaghdour Y, Bruat V, Saillour V, Healy J, Grenier JC, de Malliard T, Busche S, Spinella JF, Larivière M, Gibson G, Andersson A, Holmfeldt L, Ma J, Wei L, Zhang J, Andelfinger G, Downing JR, Mullighan CG, Awadalla P. Rare allelic forms of PRDM9 associated with childhood leukemogenesis. Genome Res 2013; 23(3): 419-430.

Frequency of chromosomally-integrated human herpesvirus 6 in children with acute lymphoblastic leukemia - Gravel A, Sinnett D, Flamand L. Frequency of chromosomally-integrated human herpesvirus 6 in children with acute lymphoblastic leukemia. PLoS ONE 2013; (12): e84322.

Integration of high-resolution methylome and transcriptome analyses to dissect epigenomic changes in childhood acute lymphoblastic leukemia - Busche S, Ge B, Vidal R, Spinella JF, Saillour V, Richer C, Healy J, Chen S, Droit A, Sinnett D, Pastinen T. Integration of high-resolution methylome and transcriptome analyses to dissect epigenomic changes in childhood acute lymphoblastic leukemia. Cancer Res 2013; 73(14): 4323-4336.

Joint genotype inference with germline and somatic mutations - Bareke E, Saillour V, Spinella JF, Vidal R, Healy J, Sinnett D, Csűrös M. Joint genotype inference with germline and somatic mutations. BMC Bioinformatics 2013; 14 suppl 5: S3. doi: 10.1186/1471-2105-14-S5-S3.

The Childhood Leukemia International Consortium - Metayer C, Milne E, Clavel J, Infante-Rivard C, Petridou E, Taylor M, Schüz J, Spector LG, Dockerty JD, Magnani C, Pombo-de-Oliveira MS, Sinnett D, Murphy M, Roman E, Monge P, Ezzat S, Mueller BA, Scheurer ME, Armstrong BK, Birch J, Kaatsch P, Koifman S, Lightfoot T, Bhatti P, Bondy ML, Rudant J, O'Neill K, Miligi L, Dessypris N, Kang AY, Buffler PA. The Childhood Leukemia International Consortium. Cancer Epidemiol 2013; 37(3): 336-347.

Bim polymorphisms: influence on function and response to treatment in children with acute lymphoblastic leukemia - Gagné V, Rousseau J, Labuda M, Sharif-Askari B, Brukner I, Laverdière C, Ceppi F, Sallan SE, Silverman LB, Neuberg D, Kutok JL, Sinnett D, Krajinovic M. Bim polymorphisms: influence on function and response to treatment in children with acute lymphoblastic leukemia. Clin Cancer Res 2013; 19(18): 5240-5249.

Whole-exome sequencing reveals a rapid change in the frequency of rare functional variants in a founding population of humans - Casals F, Hodgkinson A, Hussin J, Idaghdour Y, Bruat V, de Malliard T, Grenier JC, Gbeha E, Hamdan F, Girard S, Spinella JF, Larivière M, Saillour V, Healy J, Fernandes I, Sinnett D, Michaud JL, Rouleau GA, Haddad E, Le Deist F, Awadalla P. Whole-exome sequencing reveals a rapid change in the frequency of rare functional variants in a founding population of humans. PLoS Genet 2013; 9(9): e1003815.

Role of NOS3 DNA variants in externalizing behavioral problems observed in childhood leukemia survivors - Marcoux S, Robaey P, Gahier A, Labuda M, Rousseau J, Sinnett D, Moghrabi A, Laverdière C, Krajinovic M. Role of NOS3 DNA variants in externalizing behavioral problems observed in childhood leukemia survivors. J Pediatr Hematol Oncol 2013; 35(4): e157-162.

Association between genetic variants in the HNF4A gene and childhood-onset Crohn's disease - Marcil V, Sinnett D, Seidman E, Boudreau F, Gendron FP, Beaulieu J-F, Ménard D, Lambert MA, Bitton A, Sanchez R, Amre D, Levy E. Association between genetic variants in the HNF4A gene and childhood-onset Crohn's disease. Genes Immun 2012; 13(7): 556-565.

Functional analysis of promoter variants in KU70 and their role in cancer susceptibility - Ouimet M, Cassart P, Larivière M, Kritikou EA, Simard J, Sinnett D. Functional analysis of promoter variants in KU70 and their role in cancer susceptibility. Gene Chromosomes Cancer 2012; 51(11): 1007-1013.

Promoter polymorphisms in CHI3L1 are associated with asthma - Verlaan DJ, Ouimet M, Adoue V, Sirois-Gagnon D, Larivière M, Ge B, Beaulieu P, Dias J, Lam KC, Koka V, Laprise C, Pastinen T, Sinnett D. Promoter polymorphisms in CHI3L1 are associated with asthma. J Allergy Clin Immunol 2012; 130(2): 533-535.

Identification of functional DNA variants in the constitutive promoter region of MDM2 - Lalonde ME, Ouimet M, Larivière M, Kritikou EA, Sinnett D. Identification of functional DNA variants in the constitutive promoter region of MDM2. Human Genomics 2012; 6: 15. doi: 10.1186/1479-7364-6-15.

Polymorphism in multidrug resistance-associated protein gene 3 is associated with outcomes in childhood acute lymphoblastic leukemia - Ansari M, Sauty G, Labuda M, Gagné V, Rousseau J, Moghrabi A, Laverdière C, Sinnett D, Krajinovic M. Polymorphism in multidrug resistance-associated protein gene 3 is associated with outcomes in childhood acute lymphoblastic leukemia. Pharmacogenomics 2012; 12(5): 386-394.

CD133 expression is associated with poor outcome in neuroblastoma via chemoresistance mediated by the AKT pathway - Sartelet H, Imbriglio T, Nyalendo C, Haddad E, Annabi B, Duval M, Fetni R, Victor K, Alexandrov L, Sinnett D, Fabre M, Vassal G. CD133 expression is associated with poor outcome in neuroblastoma via chemoresistance mediated by the AKT pathway. Histopathology 2012; 60(7): 1144-1155.

Interaction between genetic and epigenetic variation defines gene expression patterns at the asthma-associated locus 17q12-q21 in lymphoblastoid cell lines - Berlivet S, Moussette S, Ouimet M, Verlaan DJ, Koka V, Al Tuwaijri A, Kwan T, Sinnett D, Pastinen T, Naumova AK. Interaction between genetic and epigenetic variation defines gene expression patterns at the asthma-associated locus 17q12-q21 in lymphoblastoid cell lines. Hum Genet 2012; 131(7): 1161-1171.

ALG: automated genotype calling of Luminex assays - Bourgey M, Larivière M, Richer C, Sinnett D. ALG: automated genotype calling of Luminex assays. PLoS ONE 2011; 6(5): e19368.

Pediatric research and the return of individual research results - Avard D, Sénécal K, Madadi P, Sinnett D. Pediatric research and the return of individual research results. J Law Med Ethics 2011; 39(4): 593-604.

Rationale for an international consortium to study inherited genetic susceptibility to childhood acute lymphoblastic leukemia - Sherborne AL, Hemminki K, Kumar R, Bartram CR, Stanulla M, Schrappe M, Petridou E, Semsei AF, Szalai C, Sinnett D, Krajinovic M, Healy J, Lanciotti M, Dufour C, Indaco S, El-Ghouroury EA, Sawangpanich R, Hongeng S, Pakakasama S, Gonzalez-Neira A, Ugarte EL, Leal VP, Espinoza JP, Kamel AM, Ebid GT, Radwan ER, Yalin S, Yalin E, Berkoz M, Simpson J, Roman E, Lightfoot T, Hosking FJ, Vijayakrishnan J, Greaves M, Houlston RS. Rationale for an international consortium to study inherited genetic susceptibility to childhood acute lymphoblastic leukemia. Haematologica 2011; 96(7): 1049-1054.

Common variants of the BRCA1 wild-type allele modify the risk of breast cancer in BRCA1 mutation carriers - Cox DG, Simard J, Sinnett D, Hamdi Y, Soucy P, Ouimet M, Barjhoux L, Verny-Pierre C, McGuffog L, Healey S, Szabo C, Greene MH, Mai PL, Andrulis I, Ontario Cancer Genetics Network, SWE-BRCA Collaborators, HEBON, EMBRACE, GEMO Study Collaborators, The Breast Cancer Family Registry, on behalf of the Consortium of Investigators of Modifiers of BRCA1/2. Common variants of the BRCA1 wild-type allele modify the risk of breast cancer in BRCA1 mutation carriers. Hum Mol Genet 2011; 20(23): 4732-4747.

ATF5 polymorphisms influence ATF function and response to treatment in children with childhood acute lymphoblastic leukemia - Rousseau J, Gagné V, Labuda M, Beaubois C, Sinnett D, Laverdière C, Moghrabi A, Sallan SE, Silverman LB, Neuberg D, Kutok JL, Krajinovic M. ATF5 polymorphisms influence ATF function and response to treatment in children with childhood acute lymphoblastic leukemia. Blood 2011; 118(22): 5883-5890.

Expression of Sar1b enhances chylomicron assembly and key components of the coat protein complex II system driving vesicle budding - Levy E, Harmel E, Laville M, Sanchez R, Emonnot L, Sinnett D, Ziv E, Delvin EE, Couture P, Marcil V, Sané AT. Expression of Sar1b enhances chylomicron assembly and key components of the coat protein complex II system driving vesicle budding. Arterioscler Thromb Vasc Biol 2011; 31(11): 2692-2699.

Novel associations between activating killer-cell immunoglobulin-like receptor genes and childhood leukemia - Almalte Z, Samarani S, Iannello A, Debbeche O, Duval M, Infante-Rivard C, Amre D, Sinnett D, Ahmad A. Novel associations between activating killer-cell immunoglobulin-like receptor genes and childhood leukemia. Blood 2011; 118(5): 1323-1328.

Genomic and genealogical investigation of the French Canadian founder population structure - Roy-Gagnon M-H, Moreau C, Bherer C, St-Onge P, Sinnett D, Laprise C, Vézina H, Labuda D. Genomic and genealogical investigation of the French Canadian founder population structure. Hum Genet 2011; 129(5): 521-531.

Genome-wide detection and characterization of mating asymmetry in human populations - Bourgey M, Healy J, St-Onge P, Massé H, Sinnett D, Roy-Gagnon M-H. Genome-wide detection and characterization of mating asymmetry in human populations. Genet Epidemiol 2011; 35(6): 526-535.

Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk - Sherborne AL, Hosking FJ, Prasad RB, Kumar R, Koehler R, Vijayakrishnan J, Papaemmanuil E, Bartram CR, Stanulla M, Schrappe M, Gast A, Dobbins SE, Ma Y, Sheridan E, Taylor M, Kinsey SE, Lightfoot T, Roman E, Irving JA, Allan JM, Moorman AV, Harrison CJ, Tomlinson IP, Richards S, Zimmermann M, Szalai C, Semsei AF, Erdelyi DJ, Krajinovic M, Sinnett D, Healy J, Neira AG, Kawamata N, Ogawa S, Koeffler HP, Hemminki K, Greaves M, Houlston RS. Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk. Nat Genet 2010; 42(6): 492-494.

The peptidomimetic CXCR4 antagonist TC14012 recruits {beta}-arrestin to CXCR7 roles of receptor domains - Gravel S, Malouf C, Boulais PE, Berchiche Y, Oishi S, Fujii N, Leduc R, Sinnett D, Heveker N. The peptidomimetic CXCR4 antagonist TC14012 recruits {beta}-arrestin to CXCR7 roles of receptor domains. J Biol Chem 2010; 285(49): 37939-37943.

Modification in oxidative stress, inflammation and lipoprotein assembly in response to hepatocyte nuclear factor 4 alpha knockdown in intestinal epithelial cells - Marcil V, Seidman E, Sinnett D, Boudreau F, Gendron FP, Beaulieu J-F, Ménard D, Précourt LP, Amre D, Levy E. Modification in oxidative stress, inflammation and lipoprotein assembly in response to hepatocyte nuclear factor 4 alpha knockdown in intestinal epithelial cells. J Biol Chem 2010; 285(52): 40448-40460.

Detection of fetomaternal genotype associations in early-onset disorders: evaluation of different methods and their application to childhood leukemia - Healy J, Bourgey M, Richer C, Sinnett D, Roy-Gagnon M-H. Detection of fetomaternal genotype associations in early-onset disorders: evaluation of different methods and their application to childhood leukemia. J Biomed  Biotechnol 2010; 2010: 369534 (on line).

Replication analysis confirms the association of ARID5B with childhood B-cell acute lymphoblastic leukemia - Healy J, Richer C, Bourgey M, Kritikou EA, Sinnett D. Replication analysis confirms the association of ARID5B with childhood B-cell acute lymphoblastic leukemia. Haematologica 2010; 95(9): 1608-1611.

Polymorphisms in glucocorticoid receptor gene and the outcome of childhood acute lymphoblastic leukemia (ALL) - Labuda M, Gahier A, Gagné V, Moghrabi A, Sinnett D, Krajinovic M. Polymorphisms in glucocorticoid receptor gene and the outcome of childhood acute lymphoblastic leukemia (ALL). Leukemia Res 2010; 34(4): 492-497.

Global patterns of cis variation in human cells revealed by high-density allelic expression analysis - Ge B, Pokholok DK, Kwan T, Grundberg E, Morcos L, Verlaan DJ, Le J, Koka V, Lam KC, Gagné V, Dias J, Hoberman R, Montpetit A, Joly MM, Harvey EJ, Sinnett D, Beaulieu P, Hamon R, Graziani A, Dewar K, Harmsen E, Majewski J, Göring HH, Naumova AK, Blanchette M, Gunderson KL, Pastinen T. Global patterns of cis variation in human cells revealed by high-density allelic expression analysis. Nat Genet 2009; 41(11): 1216-1222.

Functional impact of sequence variation in the promoter region of TGFB1 - Healy J, Dionne J, Bélanger H, Larivière M, Beaulieu P, Labuda D, Sinnett D. Functional impact of sequence variation in the promoter region of TGFB1. Int J Cancer 2009; 125(6): 1483-1489.

IL-10 and TNF-alpha promoter haplotypes are associated with childhood Crohn's disease location - Sanchez R, Levy E, Costea F, Sinnett D. IL-10 and TNF-alpha promoter haplotypes are associated with childhood Crohn's disease location. World J Gastroenterol 2009; 15(30): 3776-3782.

DNA variants in region for noncoding interfering transcript of dihydrofolate reductase gene and outcome in childhood acute lymphoblastic leukemia - Al-Shakfa F, Dulucq S, Brukner I, Milacic I, Ansari M, Beaulieu P, Moghrabi A, Laverdière C, Sallan SE, Silverman LB, Neuberg D, Kutok JL, Sinnett D, Krajinovic M. DNA variants in region for noncoding interfering transcript of dihydrofolate reductase gene and outcome in childhood acute lymphoblastic leukemia. Clin Cancer Res 2009; 15(22): 6931-6938.

Polymorphisms in multidrug resistance-associated protein gene 4 is associated with outcome in childhood acute lymphoblastic leukemia - Ansari M, Sauty G, Labuda D, Gagné V, Laverdière C, Moghrabi A, Sinnett D, Krajinovic M. Polymorphisms in multidrug resistance-associated protein gene 4 is associated with outcome in childhood acute lymphoblastic leukemia. Blood 2009; 114(7): 1383-1386.

The TP53 Arg72Pro and MDM2 309G>T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers - Sinilnikova O, Antoniou AC, Simard J, Healey S, Léoné M, Sinnett D, Spurdle AB, Beesley J, Chen X, kConFab8, Greene MH, Loud JT, Lejbkowicz F, Rennert G, Dishon S, Andrulis I, OCGN, Domchek SM, Nathanson KL, Manoukian S, Radice P, Konstantopoulou I, Blanco I, Laborde AL, Durán M, Osorio A, Benitez J, Hamann U, Hogervorst FB, van Os TA, Gille HJ, HEBON, Peock S, Cook M, Luccarini C, Evans DG, Lalloo F, Eeles R, Pichert G, Davidson R, Cole T, Cook J, Paterson J, Brewer C, EMBRACE, Hughes DJ, Coupier I, Giraud S, Coulet F, Colas C, Soubrier F, Rouleau E, Bièche I, Lidereau R, Demange L, Nogues C, Lynch H, GEMO, Schmutzler RK, Versmold B, Engel C, Meindl A, Arnold N, Sutton C, Deissler H, Schaefer D, Froster UG, GC-HBOC, Aittomäki K, Nevanlinna H, McGuffog L, Easton DF, Chenevix-Trench G, Stoppa-Lyonnet D, Consortium of Investigators of Modifiers of BRCA1/2. The TP53 Arg72Pro and MDM2 309G>T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers. Brit J Cancer 2009; 101(8): 1456-1460.

No evidence for association between TGFB1 promoter SNPs and the risk of childhood pre-B acute lymphoblastic leukemia among French Canadians - Healy J, Roy-Gagnon M-H, Sinnett D. No evidence for association between TGFB1 promoter SNPs and the risk of childhood pre-B acute lymphoblastic leukemia among French Canadians. Haematologica 2009; 94(7): 1034-1035.

Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease - Verlaan DJ, Berlivet S, Hunninghake GM, Madore AM, Larivière M, Moussette S, Grundberg E, Kwan T, Ouimet M, Ge B, Hoberman R, Swiatek M, Dias J, Lam KC, Koka V, Harmsen E, Soto-Quiros M, Avila L, Celedón JC, Weiss ST, Dewar K, Sinnett D, Laprise C, Raby BA, Pastinen T, Naumova AK. Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease. Am J Hum Genet 2009; 85(3): 377-393.

Population genomics in a disease targeted primary cell model - Grundberg E, Kwan T, Ge B, Lam KC, Koka V, Kindmark A, Mallmin H, Dias J, Verlaan DJ, Ouimet M, Sinnett D, Rivadeneira F, Estrada K, Hofman A, van Meurs JM, Uitterlinden A, Beaulieu P, Graziani A, Harmsen E, Ljunggren O, Ohlsson C, Mellström D, Karlsson MK, Nilsson O, Pastinen T. Population genomics in a disease targeted primary cell model. Genome Res 2009; 19(11): 1942-1952.

Response: MRP4 gene polymorphisms and treatment response in adult ALL - Krajinovic M, Ansari M, Sinnett D. Response: MRP4 gene polymorphisms and treatment response in adult ALL. Blood 2009; 114: 5401-5402.

Genetic heterogeneity in regional populations of Quebec-Parental lineages in the Gaspe Peninsula - Moreau C, Vézina H, Yotova V, Hamon R, de Knijff P, Sinnett D, Labuda D. Genetic heterogeneity in regional populations of Quebec-Parental lineages in the Gaspe Peninsula. Am J Phys Anthropol 2009; 139(4): 512-522.

Comparative expression analysis reveals differences in the regulation of intestinal paraoxonase family members - Précourt LP, Seidman E, Delvin EE, Amre D, Deslandres C, Dominguez M, Sinnett D, Levy E. Comparative expression analysis reveals differences in the regulation of intestinal paraoxonase family members. Int J Biochem Cell Biol 2009; 41(7): 1628-1637.

Localization, function and regulation of the two intestinal fatty acid-binding protein types - Levy E, Ménard D, Delvin EE, Montoudis A, Beaulieu J-F, Mailhot G, Dubé N, Sinnett D, Seidman E, Bendayan M. Localization, function and regulation of the two intestinal fatty acid-binding protein types. Histochem Cell Biol 2009; 132(3): 351-367.

Effect of oxydative stress on the status of adhesion molecules, nuclear receptors and cholesterol flux in endothelial cells: priming of monocytes - Marcil V, Delvin EE, Amre D, Sinnett D, Geneviève M, Seidman EG, Levy E. Effect of oxydative stress on the status of adhesion molecules, nuclear receptors and cholesterol flux in endothelial cells: priming of monocytes. Clin Med Cardiol 2008; 2: 215-218.

Connections between ETV6-modulated genes: Identification of shared features - Boily G, Beaulieu P, Healy J, Sinnett D. Connections between ETV6-modulated genes: Identification of shared features. Cancer Informatics 2008; 6: 183-200.

Anderson or chylomicron retention disease: Molecular impact of five mutations in the SAR1B gene on the structure and the functionality of Sar1b protein - Charcosset M, Sassolas A, Peretti N, Roy CC, Deslandres C, Sinnett D, Levy E, Lachaux A. Anderson or chylomicron retention disease: Molecular impact of five mutations in the SAR1B gene on the structure and the functionality of Sar1b protein. Mol Genet Metab 2008; 93(1): 74-84.

DNA variants in dihydrofolate reductase gene and outcome in childhood ALL - Dulucq S, St-Onge G, Gagné V, Ansari M, Sinnett D, Labuda D, Moghrabi A, Krajinovic M. DNA variants in dihydrofolate reductase gene and outcome in childhood ALL. Blood 2008; 111(7): 3692-3700.

Identification of transcripts modulated by ETV6 expression - Boily G, Larose J, Langlois S, Sinnett D. Identification of transcripts modulated by ETV6 expression. Brit J Haematol 2007; 136(1): 48-62.

Promoter SNPs in G1/S checkpoint regulators and their impact on the susceptibility to childhood leukemia - Healy J, Bélanger H, Beaulieu P, Larivière M, Labuda D, Sinnett D. Promoter SNPs in G1/S checkpoint regulators and their impact on the susceptibility to childhood leukemia. Blood 2007; 109(2): 683-692.

La leucémie de l'enfant - une malade génétique! - Sinnett D, N'Diaye N, St-Onge P, Healy J. La leucémie de l'enfant - une malade génétique!. Méd Sci (Paris) 2007; 23(11): 968-974.

Subcellular proteomics of cell differententiation: Quantitative analysis of the plasma membrane protein of Caco-2 cells - Pshezhetsky AV, Fediaev M, Ashmarina L, Mazur A, Budman L, Sinnett D, Labuda D, Beaulieu J-F, Ménard D, Nifantiev I, Levy E. Subcellular proteomics of cell differententiation: Quantitative analysis of the plasma membrane protein of Caco-2 cells. Proteomics 2007; 7(13): 2201-2215.

Intestinal cholesterol transport proteins: an update and beyond - Levy E, Spahis S, Sinnett D, Peretti N, Maupas-Schwalm F, Delvin EE, Lambert MA, Lavoie M. Intestinal cholesterol transport proteins: an update and beyond. Curr Opin Lipidol 2007; 18(3): 310-318.

[Teasing out the various factors associated with the digestive and absorptive phases of intestinal transport] - Levy E, Lavoie M, Delvin EE, Seidman EG, Lambert MA, Sinnett D, Sané AT, Leblond F, Spahis S, Roy CC. [Teasing out the various factors associated with the digestive and absorptive phases of intestinal transport]. Méd Sci (Paris) 2007; 23(11): 1014-1019.

Biological role, protein expression, subcellular localization and oxidative stress response of paraoxonase 2 in the intestine of humans and rats - Levy E, Trudel K, Bendayan M, Seidman EG, Delvin EE, Elchebly M, Lavoie JC, Précourt LP, Amre D, Sinnett D. Biological role, protein expression, subcellular localization and oxidative stress response of paraoxonase 2 in the intestine of humans and rats. Am J Physiol Gastrointest Liver Physiol 2007; 293(6): G1252-1261.

In vivo footprinting analysis of the Glypican 3 (GPC3) promoter region in neuroblastoma cells - Boily G, Ouellet S, Langlois S, Larivière M, Drouin R, Sinnett D. In vivo footprinting analysis of the Glypican 3 (GPC3) promoter region in neuroblastoma cells. Biochim Biophys Acta - Gene Struct Expr 2007; 1769(3): 182-193.

Patterns of variation in DNA segments upstream of transcription start sites - Labuda D, Labbé C, Langlois S, Lefebvre J-F, Freytag V, Moreau C, Sawicki J, Beaulieu P, Pastinen T, Hudson TJ, Sinnett D. Patterns of variation in DNA segments upstream of transcription start sites. Hum Mutat 2007; 28(5): 441-450.

Evaluation of BRCA1 and BRCA2 mutation prevalence, risk prediction models and a multi-step testing approach in French-Canadian high-risk breast and ovarian cancer families - Simard J, Dumont M, Moisan AM, Gaborieau V, Vézina H, Durocher F, Chiquette J, Plante M, Avard D, Bessette P, Brousseau C, Dorval M, Godard B, Houle L, Joly Y, Lajoie M-A, Leblanc G, Lépine J, Lesperance B, Malouin H, Parboosingh J, Pichette R, Provencher L, Rhéaume J, Sinnett D, Samson C, Simard JC, Tranchant M, Voyer P, Brcas I, Easton DF, Tavtigian S, Knoppers B, Laframboise R, Bridge P, Goldgar D. Evaluation of BRCA1 and BRCA2 mutation prevalence, risk prediction models and a multi-step testing approach in French-Canadian high-risk breast and ovarian cancer families. J Med Genet 2007; 44(2): 107-121.

Asymmetrical regulation of scavenger receptor class B type I by apical and basolateral stimuli using Caco-2 cells - Peretti N, Delvin EE, Sinnett D, Marcil V, Garofalo C, Levy E. Asymmetrical regulation of scavenger receptor class B type I by apical and basolateral stimuli using Caco-2 cells. J Cell Biochem 2007; 100(2) : 421-433 .

[Genetic determinants of childhood leukemia] - Sinnett D, N'Diaye N, Labuda D, Krajinovic M. [Genetic determinants of childhood leukemia]. Bull Cancer 2006; 93(9): 857-865.

Detection and characterization of DNA variants in the promoter regions of hundred of human diseases candidate genes - Sinnett D, Beaulieu P, Bélanger H, Lefebvre J-F, Langlois S, Théberge MC, Drouin S, Zotti C, Hudson T, Labuda D. Detection and characterization of DNA variants in the promoter regions of hundred of human diseases candidate genes. Genomics 2006; 87(6): 704-710.

Challenges identifying genetic determinants of pediatric cancers - the childhood leukemia experience - Sinnett D, Labuda D, Krajinovic M. Challenges identifying genetic determinants of pediatric cancers - the childhood leukemia experience. Fam Cancer 2006; 5(1): 35-47.

Localization and role of NPC1L1 in cholesterol absorption in human intestine - Sané AT, Sinnett D, Delvin EE, Bendayan M, Marcil V, Ménard D, Beaulieu J-F, Levy E. Localization and role of NPC1L1 in cholesterol absorption in human intestine. J Lipid Res 2006; 47(10): 2112-2120.

Paraoxonase 1, 2 and 3 DNA variants and susceptibility to childhood inflammatory bowel disease - del Rocio Sanchez Garcia M, Levy E, Seidman EG, Amre D, Costea F, Sinnett D. Paraoxonase 1, 2 and 3 DNA variants and susceptibility to childhood inflammatory bowel disease. Gut 2006; 55(12): 1820-1821.

Gene expression profiles of normal proliferative and differentiating human intestinal epithelial cells: a comparison with the Caco-2 cell model - Tremblay E, Auclair J, Delvin EE, Levy E, Ménard D, Pshezhetsky AV, Rivard N, Seidman EG, Sinnett D, Vachon PH, Beaulieu J-F. Gene expression profiles of normal proliferative and differentiating human intestinal epithelial cells: a comparison with the Caco-2 cell model. J Cell Biochem 2006; 99(4) : 1175-1186.

MTHFR genetic variants: an example of gene-nutrient interaction and susceptibility to childhood acute lymphoblastic leukemia - Sinnett D, Labuda D, Krajinovic M. MTHFR genetic variants: an example of gene-nutrient interaction and susceptibility to childhood acute lymphoblastic leukemia. Blood 2005; 106(7): 2590-2591.

Genetic susceptibility to childhood acute lymphoblastic leukemia - Sinnett D, Meloche C, Labuda D, Mathonnet G, Moghrabi A, Sabbagh A, Infante-Rivard C, Krajinovic M. Genetic susceptibility to childhood acute lymphoblastic leukemia. Dans: Romero RM. Trends in Leukemia Research. New York. Nova Science Publishers, Inc., 2005; 1-31.

Iron-ascorbic-induced oxidant stress and its quenching by paraoxonase I in HDL and the liver: Comparison between humans and rats - Trudel K, Sinnett D, James RW, Delvin EE, Amre D, Seidman EG, Levy E. Iron-ascorbic-induced oxidant stress and its quenching by paraoxonase I in HDL and the liver: Comparison between humans and rats. J Cell Biochem 2005; 96(2): 404-411.

Functional promoter SNPs in cell cycle checkpoint genes - Bélanger H, Beaulieu P, Moreau C, Labuda D, Hudson J, Sinnett D. Functional promoter SNPs in cell cycle checkpoint genes. Hum Mol Genet 2005; 14(18): 2641-2648.

Macrophage scavenger receptor 1 999C>T (R293X) mutation and risk of prostate cancer - Hope Q, Bullock S, Evans C, Meitz J, Hamel N, Edwards S, Severi G, Dearnaley D, Jhavar S, Southgate C, Falconer A, Dowe A, Muir K, Houlston RS, Engert JC, Roquis D, Sinnett D, Simard J, Hemdal K, Moller P, Maehle L, Badzioch M, Elees RA, Easton DF, English DR, Southey MC, Hopper JL, Foulkes W, Giles GG. Macrophage scavenger receptor 1 999C>T (R293X) mutation and risk of prostate cancer. Cancer Epidemiol Biomarmarkers Prev 2005; 14(2): 397-402.

GPC3 expression and transcripitonal regulation in cancer - Boily G, Saikali Z, Sinnett D. GPC3 expression and transcripitonal regulation in cancer. Dans: Molecular Genetics of Cancer. Transworld Research Network, 2005; 1-18.

Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia - Krajinovic M, Lamothe S, Labuda D, Lemieux-Blanchard E, Théorêt Y, Moghrabi A, Sinnett D. Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. Blood 2004; 103(1): 252-257.

Association of metabolic gene polymorphisms with tobacco consumption in healthy controls - Smits KM, Benhamou S, Gaspari L, Weijenberg MP, Alamanos Y, Ambrosone C, Autrup H, Autrup JL, Baranova H, Bathum L, Boffetta P, Brockmoller J, Butkiewicz D, Cascorbi I, Clapper ML, Coutelle C, Daly A, Dell'Omo M, Dolzan V, Duzhak TG, Farker K, Garte S, Golka K, Haugen A, Hein DW, Heon K, Hildesheim A, Hirvonen A, Hsieh L-L, Ingelman-Sundberg M, Kalina I, Kang D, Katoh T, Kihara M, Kiyohara C, Kremers P, Lazarus P, Le Marchand L, Lechner MC, London S, Manni JJ, Maugard CM, Morgan GJ, Morita S, Nazar-Stewart V, Nedelcheva Kristensen V, Oda Y, Parl FF, Peters WHM, Rannug A, Rebbeck T, Ribeiro Pinto LF, Risch A, Romkes M, Schoket B, Seidegard J, Shields P, Sinnett D, Strange RC, Stucker I, Sugimura H, To-Figueras J, Vineis P, Yu MC, Zheng W, Taioli E. Association of metabolic gene polymorphisms with tobacco consumption in healthy controls. Int J Cancer 2004; 110(2): 266-270.

Genetic diversity patterns in the SR-BI/II locus can be explained by a recent selective sweep - Le Jossec M, Wambach T, Labuda D, Sinnett D, Levy E. Genetic diversity patterns in the SR-BI/II locus can be explained by a recent selective sweep. Mol Biol Evol 2004; 21(4): 760-769.

A survey of genetic and epigenetic variation affecting human gene expression - Pastinen T, Sladek R, Gurd S, Sammak A, Ge B, Lepage P, Lavergne K, Villeneuve A, Gaudin T, Brandstrom H, Beck A, Verner A, Kingsley J, Harmsen E, Labuda D, Morgan K, Vohl M-C, Naumova AK, Sinnett D, Hudson J. A survey of genetic and epigenetic variation affecting human gene expression. Physiol Genomics 2004; 16(2): 184-193.

Methylation analysis of the glypican 3 gene in embryonal tumours - Boily G, Saikali Z, Sinnett D. Methylation analysis of the glypican 3 gene in embryonal tumours. Brit J Cancer 2004; 90(8): 1606-1611.

Polymorphisms in genes relevant for corticosteroid response and the outcome of childhood acute lymphoblastic leukemia - Fleury I, Primeau M, Costea I, Moghrabi A, Sinnett D, Krajinovic M. Polymorphisms in genes relevant for corticosteroid response and the outcome of childhood acute lymphoblastic leukemia. Am J Pharmacogenomics 2004; 4(5): 331-341.

Mutational and expression analysis of the chromosome 12p candidate tumor suppressor genes in pre-B acute lymphoblastic leukemia - Montpetit A, Larose J, Boily G, Langlois S, Trudel N, Sinnett D. Mutational and expression analysis of the chromosome 12p candidate tumor suppressor genes in pre-B acute lymphoblastic leukemia. Leukemia 2004; 18(9): 1499-1504.

Association of vitamin D receptor genetic variants with susceptibility to asthma and atopy - Poon A, Laprise C, Lemire M, Montpetit A, Sinnett D, Schurr E, Hudson TJ. Association of vitamin D receptor genetic variants with susceptibility to asthma and atopy. Am J Respir Crit Care Med 2004; 170(9): 967-973.

Genetic determinants to childhood acute lymphoblastic leukemia - Sinnett D, Mathonnet G, Meloche C, Moghrabi A, Labuda D, Krajinovic M. Genetic determinants to childhood acute lymphoblastic leukemia. Dans: Pandalai SG (ed). Recent Research Developments in Haematology. India. Transworld Research Network, 2003; 135-154.

Isolation of cosmid and BAC DNA - Sinnett D, Montpetit A. Isolation of cosmid and BAC DNA. Dans: Casali N, Preston A (eds). Methods in Molecular Biology, E. Coli plasmid vectors. Totawa, NJ. Humana Press, Inc., 2003; 99-102.

Pharmacogenetics of childhood acute lymphoblastic leukemia - Krajinovic M, Labuda D, Sinnett D. Pharmacogenetics of childhood acute lymphoblastic leukemia. Curr Pharmacogenomics 2003; 1: 87-100.

Role of DNA mismatch repair genetic polymorphisms in the risk of childhood acute lymphoblastic leukaemia - Mathonnet G, Krajinovic M, Labuda D, Sinnett D. Role of DNA mismatch repair genetic polymorphisms in the risk of childhood acute lymphoblastic leukaemia. Brit J Haematol 2003; 123(1): 45-48.

Characterization of the BclI polymorphism in the glucocorticoid receptor gene - Fleury I, Beaulieu P, Primeau M, Labuda D, Sinnett D, Krajinovic M. Characterization of the BclI polymorphism in the glucocorticoid receptor gene. Clin Chem 2003; 49(9): 1528-1531.

Prostate cancer susceptibility genes: lessions learned and challenges posed - Simard J, Dumont M, Labuda D, Sinnett D, Meloche C, El-Alfy MV, Berger L, Lees E, Labrie F, Tavtigian S. Prostate cancer susceptibility genes: lessions learned and challenges posed. Endocr-Relat Cancer 2003; 10(2): 225-259.

Inflammatory reaction without endogenous antioxidant response in caco-2 cells exposed to iron/ascorbate-mediated lipid peroxidation - Bernotti S, Seidman EG, Sinnett D, Brunet S, Dionne S, Delvin EE, Levy E. Inflammatory reaction without endogenous antioxidant response in caco-2 cells exposed to iron/ascorbate-mediated lipid peroxidation. Am J Physiol Gastrointest Liver Physiol 2003; 285(5): G898-G906.

Cellular aspects of intestinal lipoprotein assembly in Psammomys Obesus: A model of insulin resistance and type 2 diabetes - Zoltowska M, Ziv E, Delvin EE, Kalman R, Sinnett D, Garofalo C, Seidman EG, Levy E. Cellular aspects of intestinal lipoprotein assembly in Psammomys Obesus: A model of insulin resistance and type 2 diabetes. Diabetes 2003; 52(10): 2539-2545.

Analysis of the conservation of synteny between Fugu and human chromosome 12 - Montpetit A, Wilson MD, Chevrette M, Koop BF, Sinnett D. Analysis of the conservation of synteny between Fugu and human chromosome 12. BMC Genomics 2003; 4(1): 30.

Variable continental distribution of polymorphisms in the coding regions of DNA-repair genes - Mathonnet G, Labuda D, Meloche C, Wambach T, Krajinovic M, Sinnett D. Variable continental distribution of polymorphisms in the coding regions of DNA-repair genes. J Hum Genet 2003; 48(12): 659-664.

Analyses of bulky DNA adduct levels in human breast tissue and genetic polymorphisms of cytochromes P450 (CYPs), myeloperoxidase (MPO), quinone oxidoreductase (NQO1) and glutathione S-transferases (GSTs) - Brockstedt U, Krajinovic M, Richer C, Mathonnet G, Sinnett D, Pfau W, Labuda D. Analyses of bulky DNA adduct levels in human breast tissue and genetic polymorphisms of cytochromes P450 (CYPs), myeloperoxidase (MPO), quinone oxidoreductase (NQO1) and glutathione S-transferases (GSTs). Mutat Res 2002; 516(1-2): 41-47.

A detailed transcriptional map of the chromosome 12p12 tumor suppressor locus - Montpetit A, Boily G, Sinnett D. A detailed transcriptional map of the chromosome 12p12 tumor suppressor locus. Eur J Hum Genet 2002; 10(1): 62-71.

GSTT1 and CYP2E1 polymorphisms and trihalomethanes in drinking water: Effect on childhood leukemia - Infante-Rivard C, Amre D, Sinnett D. GSTT1 and CYP2E1 polymorphisms and trihalomethanes in drinking water: Effect on childhood leukemia. Environ Health Perspect 2002; 110(6): 591-593.

Glutathione-S-Transferase P1 genetic polymorphisms and susceptibility to childhood acute lymphoblastic leukemia - Krajinovic M, Labuda D, Sinnett D. Glutathione-S-Transferase P1 genetic polymorphisms and susceptibility to childhood acute lymphoblastic leukemia. Pharmacogenetics 2002; 12(8): 655-658.

Childhood acute lymphoblastic leukemia associated with parental alcohol consumption and polymorphisms of carcinogen-metabolizing genes - Infante-Rivard C, Krajinovic M, Labuda D, Sinnett D. Childhood acute lymphoblastic leukemia associated with parental alcohol consumption and polymorphisms of carcinogen-metabolizing genes. Epidemiology 2002; 13(3): 277-281.

Role of NQO1, MPO and CYP2E1 genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia - Krajinovic M, Sinnett H, Richer C, Labuda D, Sinnett D. Role of NQO1, MPO and CYP2E1 genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. Int J Cancer 2002; 97(2): 230-236.

Polymorphisms in genes encoding drugs and xenobiotic metabolizing enzymes, DNA repair enzymes, and response to treatment of childhood acute lymphoblastic leukemia - Krajinovic M, Labuda D, Mathonnet G, Labuda M, Moghrabi A, Champagne J, Sinnett D. Polymorphisms in genes encoding drugs and xenobiotic metabolizing enzymes, DNA repair enzymes, and response to treatment of childhood acute lymphoblastic leukemia. Clin Cancer Res 2002; 8(3): 802-810.

Parental genotypes in the risk of a complex disease - Labuda D, Krajinovic M, Sabbagh A, Infante-Rivard C, Sinnett D. Parental genotypes in the risk of a complex disease. Am J Hum Genet 2002; 71(1): 193-197.

Comparative analysis of the ETV6 gene in vertebrate genomes from pufferfish to human - Montpetit A, Sinnett D. Comparative analysis of the ETV6 gene in vertebrate genomes from pufferfish to human. Oncogene 2001; 20(26): 3437-3442.

Metabolic gene polymorphism frequencies in control populations - Garte S, Gaspari L, Alexandrie AK, Ambrosone C, Autrup H, Autrup JL, Baranova H, Bathum L, Benhamou S, Boffetta P, Bouchardy C, Breskvar K, Brockmoller J, Cascorbi I, Clapper ML, Coutelle C, Daly A, Dell'Omo M, Dolzan V, Dresler CM, Fryer A, Haugen A, Hein DW, Hildesheim A, Hirvonen A, Hsieh L-L, Ingelman-Sundberg M, Kalina I, Kang D, Kihara M, Kiyohara C, Kremers P, Lazarus P, Le Marchand L, Lechner MC, van Lieshout EMM, London S, Manni JJ, Maugard CM, Morita S, Nazar-Stewart V, Noda K, Oda Y, Parl FF, Pastorelli R, Persson I, Peters WHM, Rannug A, Rebbeck T, Risch A, Roelandt L, Romkes M, Ryberg D, Schoket B, Seidegard J, Shields P, Sim E, Sinnett D, Strange RC, Stucker I, Sugimura H, To-Figueras J, Vineis P, Yu MC, Taioli E. Metabolic gene polymorphism frequencies in control populations. Cancer Epidemiol Biomarmarkers Prev 2001; 10: 1239-1248.

Genetic susceptibility to breast cancer in French-Canadians: role of carcinogen-metabolizing enzymes and gene-environment interactions - Krajinovic M, Ghadirian P, Richer C, Sinnett H, Gandini S, Perret C, Lacroix A, Labuda D, Sinnett D. Genetic susceptibility to breast cancer in French-Canadians: role of carcinogen-metabolizing enzymes and gene-environment interactions. Int J Cancer 2001; 92(2): 220-225.

Childhood acute lymphoblastic leukemia: genetic determinants of susceptibility and disease outcome - Krajinovic M, Labuda D, Sinnett D. Childhood acute lymphoblastic leukemia: genetic determinants of susceptibility and disease outcome. Rev Environ Health 2001; 16(4): 263-279.

Genetic susceptibility to childhood acute lymphoblastic leukemia - Sinnett D, Krajinovic M, Labuda D. Genetic susceptibility to childhood acute lymphoblastic leukemia. Leuk Lymphoma 2000; 38(5-6): 447-462.

A chromosome 12p12.3 tumor suppressor locus involved in hematological malignancies and solid neoplasias - Sinnett D, Aïssani B, Bonan C, Montpetit A. A chromosome 12p12.3 tumor suppressor locus involved in hematological malignancies and solid neoplasias. Recent Res Dev Cancer 2000; 1: 213-227.

Expression of Glypican 3 (GPC 3) in embryonal tumors - Saikali Z, Sinnett D. Expression of Glypican 3 (GPC 3) in embryonal tumors. Int J Cancer 2000; 89(5): 418-422.

Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease - Dubinsky M, Lamothe S, Yang H, Targan SR, Sinnett D, Théorêt Y, Seidman EG. Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease. Gastroenterology 2000; 118(4): 705-713.

Risk of childhood leukemia associated with diagnostic irradiation and polymorphisms in DNA repair genes - Infante-Rivard C, Mathonnet G, Sinnett D. Risk of childhood leukemia associated with diagnostic irradiation and polymorphisms in DNA repair genes. Environ Health Perspect 2000; 108: 495-498.

Parental smoking, CYP1A1 genetic polymorphisms and childhood leukemia (Quebec, Canada) - Infante-Rivard C, Krajinovic M, Labuda D, Sinnett D. Parental smoking, CYP1A1 genetic polymorphisms and childhood leukemia (Quebec, Canada). Cancer Causes Control 2000; 11(6): 547-553.

Genetic polymorphisms of N-acetyltransferases 1 (NAT1) and 2 (NAT2) and gene-gene interaction in the susceptibility to childhood acute lymphoblastic leukemia - Krajinovic M, Richer C, Sinnett H, Labuda D, Sinnett D. Genetic polymorphisms of N-acetyltransferases 1 (NAT1) and 2 (NAT2) and gene-gene interaction in the susceptibility to childhood acute lymphoblastic leukemia. Cancer Epidemiol Biomarmarkers Prev 2000; 9(6): 557-562.

Preconceptional paternal exposure to pesticides and increased risk of childhood leukemia - Infante-Rivard C, Sinnett D. Preconceptional paternal exposure to pesticides and increased risk of childhood leukemia. Lancet 1999; 364: 1819.

Physical mapping of the G-protein coupled receptor 19 (GPR19) in chromosome 12p12.3 region frequently rearranged in cancer cells - Montpetit A, Sinnett D. Physical mapping of the G-protein coupled receptor 19 (GPR19) in chromosome 12p12.3 region frequently rearranged in cancer cells. Hum Genet 1999; 105: 162-164.

Fine physical ans transcript mapping of a 1.8 Mb region spanning the locus for childhood acute lymphoblastic leukemia on chromosome 12p12.3 - Aïssani B, Sinnett D. Fine physical ans transcript mapping of a 1.8 Mb region spanning the locus for childhood acute lymphoblastic leukemia on chromosome 12p12.3. Gene 1999; 240: 297-305.

Frequent loss of heterozygosity at the DNA mismatch-repair loci hMLH1 and HMSH3 in sporatic breast cancer - Benachenhou N, Guiral S, Gorska-Flipot I, Labuda D, Sinnett D. Frequent loss of heterozygosity at the DNA mismatch-repair loci hMLH1 and HMSH3 in sporatic breast cancer. Brit J Cancer 1999; 79(7/8): 1012-1017.

Childhood acute lymphoblastic leukemia: Is there a tumor suppressor gene in chromosome 12p12.3? - Aïssani B, Bonan C, Baccichet A, Sinnett D. Childhood acute lymphoblastic leukemia: Is there a tumor suppressor gene in chromosome 12p12.3?. Leuk Lymphoma 1999; 34: 231-239.

Susceptibility to childhood acute lymphoblastic leukaemia: Influence of CYP1A1, CYP2D6, GSTM1 and GSTT1 genetic polymorphisms - Krajinovic M, Labuda D, Richer C, Karimi S, Sinnett D. Susceptibility to childhood acute lymphoblastic leukaemia: Influence of CYP1A1, CYP2D6, GSTM1 and GSTT1 genetic polymorphisms. Blood 1999; 93: 1496-1501.

Risk of childhood leukemia: risk associated with exposure to pesticides and with gene polymorphisms - Infante-Rivard C, Labuda D, Krajinovic M, Sinnett D. Risk of childhood leukemia: risk associated with exposure to pesticides and with gene polymorphisms. Epidemiology 1999; 10: 481-487.

DNA methylation of the retinoic acid receptor beta gene in breast cancer and possible therapeutic role of 5'-aza-2'-deoxycytidine - Bovenzi V, Le NLO, Côté S, Sinnett D, Momparler LF, Momparler RL. DNA methylation of the retinoic acid receptor beta gene in breast cancer and possible therapeutic role of 5'-aza-2'-deoxycytidine. Anticancer Drugs 1999; 10: 471-476.

Rapid detection of CYP1A1, CYP2D6 and NAT2 variants by multiplex-PCR and allele-specific oligonucleotide assay - Labuda D, Krajinovic M, Richer C, Skoll A, Yotova V, Sinnett D. Rapid detection of CYP1A1, CYP2D6 and NAT2 variants by multiplex-PCR and allele-specific oligonucleotide assay. Anal Biochem 1999; 275: 84-92.

Isolation of stable bacterial artificial chromosome DNA using a modified alkaline lysis method - Sinnett D, Richer C, Baccichet A. Isolation of stable bacterial artificial chromosome DNA using a modified alkaline lysis method. Biotechniques 1998; 24: 752-754.

Demethylation by 5'-aza-2'-deoxycytidine of specific 5-methylcytosine sites in the promoter region of the retinoic acid receptor beta in human colon carcinoma cells - Côté S, Sinnett D, Momparler RL. Demethylation by 5'-aza-2'-deoxycytidine of specific 5-methylcytosine sites in the promoter region of the retinoic acid receptor beta in human colon carcinoma cells. Anticancer Drugs 1998; 9: 743-750.

Allelic instability of TBP gene in RER+tumors - Benachenhou N, Labuda D, Sinnett D. Allelic instability of TBP gene in RER+tumors. Int J Cancer 1998; 78: 525-526.

High resolution deletion mapping reveals frequent allelic losses at the DNA mismatch repair loci hMLH1 and hMSH3 in non-small cell lung cancer - Benachenhou N, Guiral S, Gorska-Flipot I, Labuda D, Sinnett D. High resolution deletion mapping reveals frequent allelic losses at the DNA mismatch repair loci hMLH1 and hMSH3 in non-small cell lung cancer. Int J Cancer 1998; 77: 173-180.

Monophyletic origin of Alu elements in primates - Zietkiewicz E, Richer C, Sinnett D, Labuda D. Monophyletic origin of Alu elements in primates. J Mol Evol 1998; 47(2): 172-182.

Genomic loci susceptible to replication errors in cancer cells - Krajinovic M, Richer C, Gorska-Flipot I, Gaboury L, Novakovic I, Labuda D, Sinnett D. Genomic loci susceptible to replication errors in cancer cells. Brit J Cancer 1998; 78(8): 981-985.

Chromosomal assignment of loci susceptible to replication errors by radiation hybrid mapping - Krajinovic M, Richer C, Lukovic L, Labuda D, Sinnett D. Chromosomal assignment of loci susceptible to replication errors by radiation hybrid mapping. Mutat Res Genomics 1998; 382: 81-83.

Allelic losses and DNA methylation at DNA mismatch-repair loci in sporadic colorectal cancer - Benachenhou N, Guiral S, Gorska-Flipot I, Michalski R, Labuda D, Sinnett D. Allelic losses and DNA methylation at DNA mismatch-repair loci in sporadic colorectal cancer. Carcinogenesis 1998; 19(11): 1925-1929.

Frequent deletion of chromosome 12p12.3 in children with acute lymphoblastic leukemia - Baccichet A, Sinnett D. Frequent deletion of chromosome 12p12.3 in children with acute lymphoblastic leukemia. Brit J Haematol 1997; 99: 107-114.

Human g-aminobutyric acid-type A receptor a5 subunit gene (GABRA5): characterization and structural organization of the 5' flanking region - Kim Y, Glatt H, Xie W, Sinnett D, Lalande M. Human g-aminobutyric acid-type A receptor a5 subunit gene (GABRA5): characterization and structural organization of the 5' flanking region. Genomics 1997; 42: 378-387.

Allelic loss in childhood acute lymphoblastic leukemia - Baccichet A, Qualman SA, Sinnett D. Allelic loss in childhood acute lymphoblastic leukemia. Leukemia Res 1997; 21(9): 817-823.

Microsatellite instability in childhood T-cell acute lymphoblastic leukemia - Baccichet A, Benachenhou N, Couture F, Leclerc JM, Sinnett D. Microsatellite instability in childhood T-cell acute lymphoblastic leukemia. Leukemia 1997; 11: 797-802.

Identification of a putative DNA replication origin in the g-aminoburytic acid receptor subunit b3 and a5 gene cluster on chromosome 15q11q13, a region associated with an allele specific DNA replication timing - Sinnett D, Woolf E, Glatt K, Kirkness EF, Nielsen TO, Zannis-Hadjopoulos M, Price GB, Lalande M. Identification of a putative DNA replication origin in the g-aminoburytic acid receptor subunit b3 and a5 gene cluster on chromosome 15q11q13, a region associated with an allele specific DNA replication timing. Gene 1996; 173: 171-177.

Insulin modulation of newly synthesized apolipoproteins B-100 and B-48 in the human fetal intestine: Gene expression and mRNA editing are not involved - Levy E, Sinnett D, Thibault L, Nguyen TD, Delvin EE, Ménard D. Insulin modulation of newly synthesized apolipoproteins B-100 and B-48 in the human fetal intestine: Gene expression and mRNA editing are not involved. FEBS Lett 1996; 393: 253-258.

Structure et dynamisme du génome humain - Labuda D, Sinnett D. Structure et dynamisme du génome humain. Le Médecin du Québec 1996; 31: 29-33.

Detection of a mutator phenotype in cancer cells by inter-Alu PCR - Krajinovic M, Richer C, Labuda D, Sinnett D. Detection of a mutator phenotype in cancer cells by inter-Alu PCR. Cancer Res 1996; 56: 2733-2737.

Overall informativity, OI, in DNA polymorphisms revealed by inter-ALU PCR. Detection of genomic rearrangements - Jarnik M, Tang J, Korab-Laskowska M, Zietkiewicz E, Cardinal G, Gorska-Flipot I, Sinnett D, Labuda D. Overall informativity, OI, in DNA polymorphisms revealed by inter-ALU PCR. Detection of genomic rearrangements. Genomics 1996; 36: 388-398.

About this page
Edited by Hoffmann Maude
Updated on 7/2/2015
Created on 9/18/2014
Alert or send a suggestion

Every dollar counts!

Thank you for your generosity.

It's people like you that allow us to accelerate research and heal more children better every year and, as such, offer among the best healthcare in the world.

It's also possible to give by mail or by calling toll-free

1-888-235-DONS (3667)

Contact Us

514 345-4931

Légal

© 2006-2014 CHU Sainte-Justine.
All rights reserved.
Terms of Use, Confidentiality, Security

Avertissement

Les informations contenues dans le site « CHU Sainte-Justine » ne doivent pas être utilisées comme un substitut aux conseils d’un médecin dûment qualifié et autorisé ou d’un autre professionnel de la santé. Les informations fournies ici le sont à des fins exclusivement éducatives et informatives.

Consultez votre médecin si vous croyez être malade ou composez le 911 pour toute urgence médicale.

CHU Sainte-Justine