Researcher

    Noël J-M Raynal , M.Sc. , Ph.D.

    noel.raynal@recherche-ste-justine.qc.ca
    Noël J-M Raynal
    Research Axis
    Immune Diseases and Cancer Axis
    Research Theme
    Cancers: mechanisms, new therapeutic approaches and disease outcomes
    Address
    CHUSJ

    Phone
    514 345-4931 #6763

    Phone
    #6763

    Title

    • Associate Professor, Department of Pharmacology and Physiology, Université de Montréal 
    • Principal investigator, CHU Sainte-Justine Research Center
    • Director of drug screening platform, CHU Sainte-Justine Research Center

    Internship opportunity(ies)

    Education

    • Postdoctoral training, MD Anderson Cancer Center, Department of Leukemia, University of Texas and Fels Institute for Cancer Research and Molecular Biology, Temple University (2009-2013) 
    • Ph.D. in Biology, INRS-Institut Armand-Frappier, Université du Québec (2003-2008)
    • M.Sc. in Biology, Université du Québec à Montréal (2001-2003)
    • Undergraduate studies in Biochemistry, Université de Montpellier (2000)

    Lab research interests

    • Epigenetic therapy of pediatric cancers
    • Epigenetic drug screening
    • 3D cell culture

    Lab members

    • Research Assistant: Annie Beaudry
    • Doctoral Student: Elodie Da Costa 
    • Masters Student: Gabrielle McInnes

    Selected Publications

    • Elodie Marie Da Costa, Gregory Armaos, Gabrielle McInnes, Annie Beaudry, Gael Moquin-Beaudry, Virginie Bertrand-Lehouillier, Maxime Caron, Chantal Richer, Pascal St-Onge, Jeffrey Johnson, Nevan Krogan, Yuka Sai, Michael Downey, Moutih Rafei, Meaghan Boileau, Kolja Eppert, Ema Flores-Diaz, Andre Haman, Trang Hoang, Daniel Sinnett, Christian Beausejour, Serge McGraw, Noël J. M. Raynal. Targeting MYC Overexpressing Leukemia with Cardiac Glycoside Proscillaridin through Downregulation of Histone Acetyltransferases. BioRxiv. doi: https://doi.org/10.1101/444133, 2018.
    • Hanghang Zhang, Somnath Pandey, Meghan Travers, Hongxing Sun, George Morton, Jozef Madzo, Woonbok Chung, Jittasak Khowsathit, Oscar Perez-Leal, Carlos A. Barrero, Carmen Merali, Yasuyuki Okamoto, Takahiro Sato, Joshua Pan, Judit Garriga, Natarajan V. Bhanu, Johayra Simithy, Bela Patel, Jian Huang, Noël J.-M. Raynal, Benjamin A. Garcia, Marlene A. Jacobson, Cigall Kadoch, Salim Merali, Yi Zhang, Wayne Childers, Magid Abou-Gharbia, John Karanicolas, Stephen B. Baylin, Cynthia A. Zahnow, Jaroslav Jelinek, Xavier Grana, and Jean-Pierre J. Issa. Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer. Cell, 175; 1-15, 2018.
    • Elodie M. Da Costa, Gabrielle McInnes, Annie Beaudry, and Noël J.-M. Raynal. DNA methylation targeted drugs. The Cancer Journal: The Journal of Principles & Practice of Oncology, 2017 Sep/Oct;23(5):270-276.
    • Noël J-M Raynal, Elodie Da Costa, Justin Lee, Gabriel Malouf, Sarah Dumont, Vazganush Gharibyan, Saira Ahmed, and Jean-Pierre J. Issa. Repositioning FDA-Approved Drugs in Combination with Epigenetic Drugs to Reprogram Colon Cancer Epigenome. Molecular Cancer Therapeutics, February 1 2017 16 (2) 397-407.
    • Noël J-M Raynal, Justin Lee, Youjun Wang, Annie Beaudry, Judith Garriga, Gabriel Malouf, Sarah Dumont, Elisha J Dettman, Vazganush Gharibyan, Saira Ahmed, Woonbuk Chung, Jaroslav Jelinek, Stephen B. Baylin, Don Gill, and Jean-Pierre J. Issa. Targeting Calcium signaling to induce epigenetic reactivation of tumor suppressor genes in cancer. Cancer Research. 2016 Mar 15;76(6):1494-505. doi: 10.1158/0008-5472.CAN-14-2391.
 

Every dollar counts!

Thank you for your generosity.

It's people like you that allow us to accelerate research and heal more children better every year and, as such, offer among the best healthcare in the world.

It's also possible to give by mail or by calling toll-free

1-888-235-DONS (3667)

Contact Us

514 345-4931

Légal

© 2006-2014 CHU Sainte-Justine.
All rights reserved.
Terms of Use, Confidentiality, Security

Avertissement

Les informations contenues dans le site « CHU Sainte-Justine » ne doivent pas être utilisées comme un substitut aux conseils d’un médecin dûment qualifié et autorisé ou d’un autre professionnel de la santé. Les informations fournies ici le sont à des fins exclusivement éducatives et informatives.

Consultez votre médecin si vous croyez être malade ou composez le 911 pour toute urgence médicale.

CHU Sainte-Justine