Noël J-M Raynal , M.Sc. , Ph.D.
    Noël J-M Raynal
    Research Axis
    Immune Diseases and Cancer Axis
    Research Theme
    Cancers: mechanisms, new therapeutic approaches and disease outcomes

    514 345-4931 #6763



    • Associate Professor, Department of Pharmacology and Physiology, Université de Montréal 
    • Principal investigator, CHU Sainte-Justine Research Center
    • Director of drug screening platform, CHU Sainte-Justine Research Center

    Internship opportunity(ies)


    • Postdoctoral training, MD Anderson Cancer Center, Department of Leukemia, University of Texas and Fels Institute for Cancer Research and Molecular Biology, Temple University (2009-2013) 
    • Ph.D. in Biology, INRS-Institut Armand-Frappier, Université du Québec (2003-2008)
    • M.Sc. in Biology, Université du Québec à Montréal (2001-2003)
    • Undergraduate studies in Biochemistry, Université de Montpellier (2000)

    Lab research interests

    • Epigenetic therapy of pediatric cancers
    • Epigenetic drug screening
    • 3D cell culture

    Lab members

    • Research Assistant: Annie Beaudry
    • Doctoral Student: Elodie Da Costa 
    • Masters Student: Gabrielle McInnes

    Selected Publications

    • Elodie Marie Da Costa, Gregory Armaos, Gabrielle McInnes, Annie Beaudry, Gael Moquin-Beaudry, Virginie Bertrand-Lehouillier, Maxime Caron, Chantal Richer, Pascal St-Onge, Jeffrey Johnson, Nevan Krogan, Yuka Sai, Michael Downey, Moutih Rafei, Meaghan Boileau, Kolja Eppert, Ema Flores-Diaz, Andre Haman, Trang Hoang, Daniel Sinnett, Christian Beausejour, Serge McGraw, Noël J. M. Raynal. Targeting MYC Overexpressing Leukemia with Cardiac Glycoside Proscillaridin through Downregulation of Histone Acetyltransferases. BioRxiv. doi:, 2018.
    • Hanghang Zhang, Somnath Pandey, Meghan Travers, Hongxing Sun, George Morton, Jozef Madzo, Woonbok Chung, Jittasak Khowsathit, Oscar Perez-Leal, Carlos A. Barrero, Carmen Merali, Yasuyuki Okamoto, Takahiro Sato, Joshua Pan, Judit Garriga, Natarajan V. Bhanu, Johayra Simithy, Bela Patel, Jian Huang, Noël J.-M. Raynal, Benjamin A. Garcia, Marlene A. Jacobson, Cigall Kadoch, Salim Merali, Yi Zhang, Wayne Childers, Magid Abou-Gharbia, John Karanicolas, Stephen B. Baylin, Cynthia A. Zahnow, Jaroslav Jelinek, Xavier Grana, and Jean-Pierre J. Issa. Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer. Cell, 175; 1-15, 2018.
    • Elodie M. Da Costa, Gabrielle McInnes, Annie Beaudry, and Noël J.-M. Raynal. DNA methylation targeted drugs. The Cancer Journal: The Journal of Principles & Practice of Oncology, 2017 Sep/Oct;23(5):270-276.
    • Noël J-M Raynal, Elodie Da Costa, Justin Lee, Gabriel Malouf, Sarah Dumont, Vazganush Gharibyan, Saira Ahmed, and Jean-Pierre J. Issa. Repositioning FDA-Approved Drugs in Combination with Epigenetic Drugs to Reprogram Colon Cancer Epigenome. Molecular Cancer Therapeutics, February 1 2017 16 (2) 397-407.
    • Noël J-M Raynal, Justin Lee, Youjun Wang, Annie Beaudry, Judith Garriga, Gabriel Malouf, Sarah Dumont, Elisha J Dettman, Vazganush Gharibyan, Saira Ahmed, Woonbuk Chung, Jaroslav Jelinek, Stephen B. Baylin, Don Gill, and Jean-Pierre J. Issa. Targeting Calcium signaling to induce epigenetic reactivation of tumor suppressor genes in cancer. Cancer Research. 2016 Mar 15;76(6):1494-505. doi: 10.1158/0008-5472.CAN-14-2391.

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