Isabel Fernandez , Ph.D.
    Research Axis
    Immune Diseases and Cancer Axis

    514 345-4931 #3215


    • Associate Researcher, Sainte-Justine University Hospital Research Center
    • Docteur en Sciences Biologique. Spécialiste clinique en biologie médical. CHU-Sainte Justine
    • Professeure adjointe de clinique. Department of Microbiology, Infectiology and Immunology, University of Montreal


    • Senior Researcher, European Union, Laboratoire d'Immunologie Clinique. Institut Curie, Paris, France, 2005-2008
    •  Senior Researcher. Programa Ramón y Cajal. IDIBAPS, Dept. Biologia Cel.lular i Anatomia Pathològica, Faculty of Medicine, University of Barcelona. Barcelona, Spain, 2004-2005
    •  Postdoctoral, Unité de Pathogénie Microbienne Moléculaire. Institut Pasteur, Paris, France, 2000-2004
    •  Postdoctoral, Gastroentérologie Pédiatrique et Nutrition. Hôpital Général de Massachusetts et Faculté de Medicine de l’Université de Harvard, Boston, USA, 1995-1999
    •  Ph.D.Biology (Cell Biology) University of Granada. Granada, Spain, 1995
    •  B.A. Biology. Faculty of Sciences, University of Granada. Granada, Spain., 1990

    Research Interests

    During my scientific career, I have acquired a combination of technical competences and scientific knowledge applied to different biological and physiological processes, mainly immunologic, molecular and cellular mechanisms involved in inflammatory process, as well as the study of pathologies affecting innate immunity responses at the initial events of infection and/or inflammation.

    At the present, my researcher area has became clinical, essentially for the development of new approaches for diagnosis of immune defects and anomalies on host-pathogen crosstalk in children, for the study of mechanisms involved in dysfunctions of immune responses in children, and for the analysis of the immune reconstitution after treatment and/or hematopoietic stem cell transplantation.

    Research Topics

    • Hereditary immunodeficiencies
    • Innate immunity and infections
    • Molecular and cellular mechanisms involved in immunodeficiencies


    • Are Defects in Innate Immunity Associated with Invasive Group A Streptococcal Infections in Children?. Immunology Symposium, Toronto, Octobre 2013.
    • Cellules dendritiques des muqueuses: du fondamental à l'infection VIH. Mucosal dendritic cells: from basic science to HIV infection. Institut Cochin, Paris, France, 2009.
    • Epithelial Cell-Dendritic Cell Crosstalk and Immune Evasion in Human Papillomavirus infection. 5th International Conference on Innate Immunity. Crete, Greece, 2009.


    • M Picard, MI Fernandez, Anne Des Roches, Philippe Bégin, Jean Paradis, Louis Paradis Françoise Le Deist.. Ceftazidime-induced drug reaction with eosinophilia and systemic symptoms (DRESS) complicated by hemophagocytic lymphohistiocytosis. J Allergy Clin Immunol: In Practice 2013; 1:409-412.
    • Samuels ME , Majewski J , Alirezaie N , Fernandez I , Casals F , Patey N , Decaluwe H , Gosselin I , Haddad E , Hodgkinson A , Idaghdour Y, Marchand V , Michaud JL , Rodrigue MA, Desjardins S , Dubois S , Le Deist F , Awadalla P , Raymond V , Maranda B. Exome sequencing identifies mutations in the gene TTC7A in French-Canadian cases with hereditary multiple intestinal atresia. J Med Genet. 2013; 50: 324–329.
    • Fernandez MI, Heuzé ML, Martinez-Cingolani C, Volpe E, Donnadieu MH, Piel M, Homey B, Lennon-Duménil AM, Soumelis V. The human cytokine TSLP triggers a cell autonomous dendritic cell migration in confined environments. Blood 2011; 118: 3862-3869.
    • Fernandez MI, Regnault B, Mulet C, Tanguy M, Jay P, Sansonetti PJ, Pédron T. Maturation of Paneth cells induces the refractory state of newborn mice to Shigella infection. J Immunol 2008; 180:4924-4930.
    • Fernandez MI, Pedron T, Tournebize R, Olivo-Marin J-C, Sansonetti PJ, Phalipon A. Anti-inflammatory role for intracellular dimeric immunoglobulin A by neutralization of lipopolysaccharide in epithelial cells. Immunity 2003 ; 18:739-749.

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