Researcher

    Michèle Brochu , Ph.D.

    michele.brochu@umontreal.ca
    Michèle Brochu
    Research Axis
    Fetomaternal and Neonatal Pathologies
    Research Theme
    Fetal development and prematurity
    Address
    CHUSJ

    Phone
    514 345-4931 #5035

    Fax
    514 345-4801

    Career Summary

    Our major research interests are related to feto-maternal health.

    In collaboration with Dr Jean St-Louis, we are particularly interested in maternal factors that could be implicated in intrauterine growth restriction and hypertension in pregnancy. We have developed two experimental rat models, one of intrauterine growth restriction (IUGR) and another of hypertension in pregnancy. These models are used to better understand the organ and cellular mechanisms implicated in these diseases. A better understanding of the causes of these diseases could lead to better prevention and/or treatment.

    An unfavourable fetal environment could lead to diseases that occur in adult life such as hypertension, diabetes and obesity. We used the IUGR model animals in order to better understand this fetal programming of adult disease. We have shown that an unfavourable fetal environment leads to heart, kidney and adrenal alterations that could be implicated in the physiological and morphological changes leading to the development of adult diseases. We recently discovered that the reproductive system of IUGR model animals is also affected. We are therefore investigating the mechanisms involved.

    Scientific Collaborations

    Dr Jean St-Louis, CHU Sainte-Justine Research Center.

    Dr Nicole Gallo-Payet, Service of Endocrinology, Faculty of Medicine, University of Sherbrooke.

    We have developed our own models and are working in collaboration to bring forth an integrative aspect by conducting studies on the mother as well as the child.

About this page
Edited by Hoffmann Maude

Created on 9/18/2014
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