Dr. Pincez's research laboratory aims to use clinical, genetic, and genomic tools to improve the understanding, stratification, and prognosis of autoimmune cytopenias and red blood cell disorders. The objective is to bring the benefits of these approaches to patients in order to adapt and personalize care. To that end, they use different DNA sequencing approaches to study the effect of rare and frequent constitutional variants as well as somatic variants (clonal hematopoiesis). They also use RNA sequencing and proteomics approaches, coupled with clinical data in an integrative approach.
Career Summary
Dr. Pincez completed his clinical training in pediatrics and then in pediatric hematology-oncology at Paris Descartes University and at CHU Sainte-Justine. His clinical practice and research interests focus on classical (non-malignant) hematology, particularly in autoimmune cytopenias and red blood cell disorders. He has carried out numerous clinical research studies in order to identify prognostic subgroups of the evolution and response to treatments in these two groups of pathologies. He also completed a master's degree in immunology at Paris Est-Créteil University and a PhD in molecular biology supervised by Pr Guillaume Lettre at the Montreal Heart Institute. During his PhD, Dr. Pincez used different genetic tools (study of clonal hematopoiesis, genome-wide association studies, polygenic scores, Mendelian randomization and CRISPR/Cas9 genetic screening) in order to identify the effect of genetic variations on the expression of sickle cell disease, and conversely the effect sickle cell disease on the expression of genetic determinants.
Research laboratory
Precision globulomics