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Clinical Research Units

Clinical Research Group - Pediatric Intensive Care Unit (CRG-PICU)

Unit Presentation

The CRG-PICU is made up of pediatric intensivists and investigators who have set up a multidisciplinary team that serves as a research platform to study children and adults in intensive care. The group’s main objective is to conduct studies that will advance knowledge on respiratory assistance, multiple organ dysfunction syndrome, pharmacology, patient outcome, as well as clinical, palliative and terminal care. The research will have a positive impact on the quality of care given to intensive care patients.

The group provides Master’s, doctoral and postdoctoral training and liaises with the Blood Transfusion Research Group (RGBT).

Affiliations

Membership and collaboration

Joannie Blanchette, BSc Pharmacology, MSc Pharmaceutical Sciences
Clinical Research Assistant
Tel.: 514-345-4931, Ext. 6343

Pascal J. Brabant, RN
Clinical Research Consultant (Monitoring)
Tel.: 514-531-3936

Elena Caraman
Senior Research Clerk
Tel.: 514-345-4931, Ext. 3873

Lucy Clayton, BSc Microbiology, MSc Microbiology
Project Manager
Tel.: 514-345-4931, Ext. 6343

Thierry Ducruet, MSc Biostatistics
Statistician
Tel.: 514-345-4931, Ext. 7241

Mariana Dumitrascu, foreign MD (Romania)
Clinical Research Assistant
Tel.: 514-345-4931, Ext. 6648

Liliana Gomez Cardona, MSc Anthropology
PhD student en Anthropology

Isabelle Grisoni, Graduate Nurse (France)
Clinical Research Assistant
Tel.: 514-345-4931, Ext. 2760

Jeannette Hernandez
Administrative Research Assistant
Tel.: 514-345-4931, Ext. 4133

Patrice Hernet, Eng. PhD
Information Systems Consultant

Abbas Kerim-Dikeni, Foreign MD (Serbia)
Project Manager
Tel.: 514-345-4931, Ext. 6343

Noémie Loron-Nguyen Ngoc, Foreign MD (France)
Clinical Research Assistant
Tel.: 514-345-4931, Ext. 4132

Caroline Proulx-Clerc, Graduate Nurse (Switzerland)
Clinical Research Assistant
Tel.: 514-345-4931, Ext. 2760

Nicole Poitras, BSc Biology, DAP (graduate degree in public administration)
Senior Project Manager, Team Leader
Tel.: 514-345-4931, Ext. 2157

Ferima Sanogo, BSc Biology, MSc Health Administration
Clinical Research Assistant
Tel.: 514-345-4931, Ext. 2760

Maggy Wassef, MSc Health Technology
Research Assistant

Fellows and students

  • Fahad Alsohine
  • David Brossier
  • Laurence Ducharme-Crevier
  • Geneviève Dupont-Thibodeau
  • Alexandrine Larouche
  • Florent Baudin
  • Geneviève Morissette
  • Justine Rouette
  • Nadia Roumeliotis
  • Mickael Sauthier
  • Andréanne Villeneuve
  • Jean-Sébastien Tremblay Roy
  • Nesrine Zaglam

Significant clinical research publications

  1. Fléchelles O, Fowler R, Jouvet P. H1N1 pandemic: clinical and epidemiologic characteristics of the Canadian pediatric outbreak. Expert Rev Anti Infect Ther. 2013 Jun; 11(6):555-63.
  2. Flechelles O, Ho A, Hernert P, Emeriaud G, Zaglam N, Cheriet F, Jouvet P Simulations for mechanical ventilation in children: review and future prospects. Crit Care Res Pract. 2013; 2013:943281.
  3. Ducharme-Crevier L, Du Pont-Thibodeau G, Emeriaud G. Interest of monitoring diaphragmatic electrical activity in the pediatric intensive care unit. Crit Care Res Pract. 2013; 2013:384210.
  4. Jouvet P, Payen V, Gauvin F, Emeriaud G, Lacroix J. Weaning children from mechanical ventilation with a computer-driven protocol: a pilot trial. Intensive Care Med. 2013 May; 39(5):919-25.
  5. Rose L, Schultz MJ, Cardwell CR, Jouvet P, McAuley DF, Blackwood B. Automated versus non-automated weaning for reducing the duration of mechanical ventilation for critically ill adults and children. Cochrane Database Syst Rev. 2013 Jun 6; 6:CD009235.
  6. Leteurtre S, Duhamel A, Salleron J, Grandbastien B, Lacroix J, Leclerc F; Groupe Francophone de Réanimation et d’Urgences Pédiatriques (GFRUP) PELOD-2: An update of the PEdiatric Logistic Organ Dysfunction Score. Crit Care Med. 2013 Jul; 41(7):1761-73.
  7. Fontana MS, Farrell C, Gauvin F, Lacroix J, Janvier A. Modes of Death in Pediatrics: Differences in the Ethical Approach in Neonatal and Pediatric Patients. J Pediatr. 2013 Jun; 162(6):1107-11. Epub 2013 Jan 11
  8. Carnevale FA, Farrell C, Cremer R, Canoui P, Séguret S, Gaudreault J, de Bérail B, Lacroix J, Leclerc F, Hubert P. Struggling to do what is right for the child: pediatric life-support decisions among physicians and nurses in France and Quebec. J Child Health Care. 2012 Jun; 16(2):109-23.
  9. Demaret P, Pettersen G, Hubert P, Teira P, Emeriaud G. The critically-ill pediatric hemato-oncology patient: epidemiology, management, and strategy of transfer to the pediatric intensive care unit. Ann Intensive Care. 2012 Jun 12; 2(1):14.
  10. Jouvet P, Eddington A, Payen V, Bordessoule A, Emeriaud G, Gasco RL, Wysocki M. A pilot prospective study on closed loop controlled ventilation and oxygenation in ventilated children during the weaning phase. Crit Care. 2012 May 16; 16(3):R85.
  11. Bordessoule A, Emeriaud G, Morneau S, Jouvet P, Beck J Neurally adjusted ventilatory assist improves patient–ventilator interaction in infants as compared with conventional ventilation. Pediatr Res. 2012 Aug; 72(2):194-202.
  12. Parshuram CS, Duncan HP, Joffe AR, Farrell CA, Lacroix JR, Middaugh KL, Hutchison JS, Wensley D, Blanchard N, Beyene J, Parkin PC Multicentre validation of the bedside paediatric early warning system score: a severity of illness score to detect evolving critical illness in hospitalised children. Crit Care. 2011 Aug 3; 15(4):R184.
  13. Launay E, Théôret Y, Litalien C, Duval M, Alvarez F, Lapeyraque AL, Phan V, Larocque D, Poirier N, Lamarre V. Pharmacokinetic Profile of Valganciclovir in Pediatric Transplant Recipients. Ovetchkine P.Pediatr Infect Dis J. 2011 Dec 23. [Epub ahead of print] PMID: 22198827 [PubMed - as supplied by publisher]
  14. Merouani A, Kechaou W, Litalien C, Ducruet T, Jouvet P. Impact of blood volume monitoring on fluid removal during intermittent hemodialysis of critically ill children with acute kidney injury. Nephrol Dial Transplant. 2011 Oct; 26(10):3315-9. Epub 2011 Feb 17.
  15. Jouvet P, Hernert P, Wysocki M. Development and implementation of explicit computerized protocols for mechanical ventilation in children. Ann Intensive Care. 2011 Dec 21;1(1):51.
  16. Parshuram CS, Duncan HP, Joffe AR, Farrell CA, Lacroix JR, Middaugh KL, Hutchison JS, Wensley D, Blanchard N, Beyene J, Parkin PC. Multicentre validation of the bedside paediatric early warning system score: a severity of illness score to detect evolving critical illness in hospitalised children. Crit Care. 2011 Aug 3;15(4):R184.
  17. Alkandari O, Eddington KA, Hyder A, Gauvin F, Ducruet T, Gottesman R, Phan V, Zappitelli M Acute kidney injury is an independent risk factor for pediatric intensive care unit mortality, longer length of stay and prolonged mechanical ventilation in critically ill children: a two-center retrospective cohort study. Crit Care. 2011 Jun 10; 15(3):R146.
  18. Emeriaud G, Pettersen G, Ozanne B Pediatric traumatic brain injury: an update. Curr Opin Anaesthesiol. 2011 Jun; 24(3):307-13. Review.
  19. Dupuis C, Thomas S, Faure P, Gayot A, Desrumaux A, Wroblewski I, Debillon T, Emeriaud G. Secondary adrenal insufficiency in the acute phase of pediatric traumatic brain injury. Intensive Care Med. 2010 Nov; 36(11):1906-13. doi: 10.1007/s00134-010-2012-4. Epub 2010 Aug 6.
  20. Jouvet P, Hutchison J, Pinto R, Menon K, Lacroix J, Choong K, Kesselman M, Veroukis S, Dugas MA, Santschi M, Guerguerian AM, Withington D, Alsaati B, Joffe A, Skippen P, Kumar A and Fowler R for the Canadian Critical Care Trials Group H1N1 Collaborative. Critical Illness in Children with Swine Origin Influenza A/H1N1. Pediatr Crit Care Med 2010; 11(5):603-609.
  21. Fowler R, Jouvet P. Pediatric mortality from H1N1. Lancet 2010;376:1808-10 (Editorial)
  22. Emeriaud G, Baconnier P, Eberhard A, Debillon T, Calabrese P, Benchetrit G. Variability of end expiratory lung volume in premature infants. Neonatology 2010; 98:321-9.
  23. Santschi M, Jouvet P, Leclerc F, Gauvin F, Newth CJ, Carroll CL, Flori H, Tasker RC, Rimensberger PC, Randolph AG; PALIVE Investigators; Pediatric Acute Lung Injury and Sepsis Investigators Network (PALISI); European Society of Pediatric and Neonatal Intensive Care (ESPNIC)., "Acute lung injury in children: therapeutic practice and feasibility of international clinical trials.", Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 11(6)
  24. Bourdages M, Bigras JL, Farrell CA, Hutchison JS, Lacroix J; Canadian Critical Care Trials Group. Cardiac arrhythmias associated with severe traumatic brain injury and hypothermia therapy. Pediatr Crit Care Med. 2010 May;11(3):408-14
  25. Emeriaud G. Traumatisme crânien grave de l’enfant : prise en charge en réanimation, principaux objectifs. Ann Fr Anesth Reanim 2009; 28(7-8):690-1.
  26. Kumar A, Zarychanski R, Pinto R, Cook D, Marshall J, Lacroix J, Stelfox T, Bagshaw S, Choong K, Lamontagne F, Turgeon A, Lapinsky S, Ahern SP, Smith O, Siddiqui F, Jouvet P, Khwaja K, McIntyre L, Menon K, Hutchison J, Hornstein D, Joffe A, Lauzier F, Singh J, Karachi T, Wiebe K, Olafson K, Ramsey C, Sharma S, Dodek P, Meade M, Hall R, Fowler R, for the Canadian Critical Care Trials Group H1N1 Collaborative. Critically Ill Patients with Novel Swine Origin Influenza Virus A/H1N1 Infection in Canada. JAMA 2009; 302(17): 1872-9 (impact factor: 31.7).
  27. Doherty DR, Parshuram CS, Gaboury I, Hoskote A, Lacroix J, Tucci M, Joffe A, Choong K, Farrell R, Bohn DJ, Hutchison JS. Hypothermia therapy after pediatric cardiac arrest. Circulation 2009; 119:1492-500.
  28. Hirshberg E, Lacroix J, Sward K, Willson D, Morris AH. Blood glucose control in critically ill adults and children: a survey on stated practice. Chest 2008; 133:1328-35.
  29. Hutchison JS, Ward RE, Lacroix J, Hebert PC, Barnes MA, Bohn DJ, Dirks PB, Doucette S, Fergusson D, Gottesman R, Joffe AR, Kirpalani HM, Meyer PG, Morris KP, Moher D, Singh RN, Skippen PW. Hypothermia therapy after traumatic brain injury in children. N Engl J Med 2008; 358:2447-56.
  30. Simon L, Saint-Louis P, Amre DK, Lacroix J, Gauvin F., "Procalcitonin and Creactive protein as markers of bacterial infection in critically ill children at onset of systemic inflammatory response syndrome.", Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies., 9(4)
  31. Sapieha P, Sirinyan M, Hamel D, Zaniolo K, Joyal JS, Cho JH, Honore JC, Kermorvant-Duchemin E, Varma DR, Tremblay S, Leduc M, Rihakova L, Hardy P, Klein WH, Mu X, Mamer O, Lachapelle P, Di Polo A, Beausejour C, Andelfinger G, Mitchell G, Sennlaub F, Chemtob S. The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis. Nat Med 2008; 14:1067-76.
  32. Bailey D, Phan V, Litalien C, Ducruet T, Merouani A, Lacroix J, Gauvin F. Risk factors of acute renal failure in critically ill children: A prospective descriptive epidemiological study. Pediatr Crit Care Med 2007; 8:29-35.
  33. Dubois J, Rypens F, Garel L, David M, Lacroix J, Gauvin F. Incidence density of deep vein thrombosis related to peripherally inserted central catheters (PICC) in children. CMAJ 2007; 177:1185-90.
  34. Santschi M, Gauvin F, Hatzakis G, Lacroix J, Jouvet P. Acceptable respiratory physiologic limits for children during weaning from mechanical ventilation. Intensive Care Med 2007; 33:319-25.
  35. Sinderby C, Beck J, Spahija J, de Marchie M, Lacroix J, Navalesi P, Slutsky AS. Inspiratory muscle unloading by neurally adjusted ventilatory assist during maximal inspiratory efforts in healthy subjects. Chest 2007; 131:711-7.
  36. Decaluwe H, Harrison LM, Mariscalco MM, Gendrel D, Bohuon C, Tesh VL, Proulx F. Procalcitonin in children with Escherichia coli O157:H7 associated hemolytic uremic syndrome. Pediatr Res 2006; 59:579-83.
  37. Emeriaud G, Beck J, Tucci M, Lacroix J, Sinderby C. Diaphragm electrical activity during expiration in mechanically ventilated infants. Pediatr Res 2006; 59:705-10.
  38. Hutchison J, Ward R, Lacroix J, Hébert P, Skippen P, Barnes M, Meyer P, Morris K, Kirpalani H, Singh R, Dirks P, Bohn D, Moher D, for the Hyp-HIT Investigators and the Canadian Critical Care Trials Group. Hypothermia pediatric had injury trial: the value of a pretrial clinical evaluation phase. Dev Neurosci 2006;28:291-301.
  39. Ennaciri J, Menezes J, Proulx F, Toledano BJ. Induction of apoptosis by herpes simplex virus-1 in neonatal, but not adult, neutrophils. Pediatr Res 2005; 59:7-12.
  40. Jouvet P, Hubert P, Saudubray JM, Rabier D, Man NK. Kinetic modeling of plasma leucine levels during continuous venovenous extracorporeal removal therapy in neonates with maple syrup urine disease. Pediatr Res 2005; 58:278-82.
  41. Leclerc F, Leteurtre S, Duhamel A, Grandbastien B, Proulx F, Martinot A, Gauvin F, Hubert P, Lacroix J. Cumulative influence of organ dysfunctions and septic state on mortality of critically ill children. Am J Respir Crit Care Med 2005; 171:348-53.
  42. Litalien C, Theoret Y, Faure C. Pharmacokinetics of proton pump inhibitors in children. Clin Pharmacokinet 2005; 44:441-66.
  43. Leteurtre S, Martinot A, Duhamel A, Proulx F, Grandbastien B, Cotting J, Gottesman R, Joffe A, Pfenninger J, Hubert P, Lacroix J, Leclerc F. Validation of the paediatric logistic organ dysfunction (PELOD) score: prospective, observational, multicentre study. Lancet 2003; 362:192-7.

Books

  1. Emeriaud G "Neurally adjusted ventilatory assist (NAVA).", In : Rimensberger P éds. Pediatric and neonatal ventilation. From basics to clinical practice., Springer
  2. Tucci M, Lacroix J, Gauvin F, Toledano B, Robitaille N. Transfusion medicine. In: Wheeler DS, Wong HR, Shanley TP, eds. Pediatric critical care medicine: Basic science and clinical evidence. 2nd edition. London: Springer-Verlag 2012:in press
  3. Lacroix J, Gauthier M, Hubert P, Leclerc F, Gaudreault P. Urgences et soins intensifs pédiatriques (Pediatric emergency and critical care). Montréal & Paris: Les Éditions du CHU Sainte-Justine & Elsevier-Masson; 2007

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