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Clinical research and knowledge transfer unit on childhood asthma (CRUCA)

Determinants of Oral Corticosteroid Responsiveness In Wheezing Asthmatic Youth (DOORWAY)

Oral corticosteroids are the cornerstone of the treatment of a moderate to severe asthma attack at the emergency department. The purpose of this study is to identify if certain factors reduce the response to oral steroids and increase the risk of hospitalization. The studied factors are the age of the child, the sex, triggering factors (such as viral infections) and exposure to tobacco smoke. We believe that a decrease in the response to treatment may be modulated by the nature of the inflammation in the airways during the asthma flare-up and the genetic make-up of the child.

Principal investigator at the CHU Sainte-Justine
Francine M. Ducharme, M.D., M.Sc., pediatrician and clinical epidemiologist, CHU Sainte-Justine

Co-investigators

  • Dominic Chalut, M.D., emergency physician,
    Montreal Children’s Hospital of the McGill University Health Center
  • Jocelyn Gravel, M.D., emergency physician,
    CHU Sainte-Justine (Montreal)
  • Marie-Claude Guertin, Ph.D, biostatistician,
    Montreal Heart Institute Coordinating Center
  • Naveen Poonai, M.D., emergency physician,
    Children’s Hospital of the London Health Sciences Centre
  • Maja Krajinovic, Ph.D., geneticist,
    CHU Sainte-Justine
  • Sophie Laberge, M.D., pediatric respirologist,
    CHU Sainte-Justine
  • Catherine Lemière, M.D., adult respirologist,
    Hôpital du Sacré-Coeur de Montréal
  • Caroline Quach-Thanh, M.D., pediatric infectious diseases specialist,
    Montreal Children’s Hospital of the McGill University Health Center
  • Roger Zemek, M.D., emergency physician,
    Children’s Hospital of Eastern Ontario

Institutions involved
Sainte-Justine University Health Centre
Montreal Children’s Hospital of the McGill University Health Centre
Children’s Hospital of the London Health Sciences Centre
Children’s Hospital of Eastern Ontario

Granting organization
Canadian Institutes of Health Research (CIHR)

Financing
1 899 255 $

Study Duration
April 2010 - March 2014

Project team
Bhupendrasinh Chauhan (Research coordinator)
Marie-France Goyer (Assistant coordinator)
Francine Picotin (Research respiratory therapist)
Garry Cormier (Research respiratory therapist)

For more information, contact Bhupendrasinh Chauhan at 514-345-4931, ext. 4997.

About this page
Updated on 10/15/2014
Created on 10/14/2014
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