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Effectiveness of Metformin to help improve daily living for individuals with Fragile X Syndrome

Metformin Clinical Trial

Researchers are testing the effectiveness of Metformin to help improve daily living for individuals with Fragile X Syndrome (FXS).

Why do this study?

We are attempting to further assess Metformin’s safety, as well as the benefits of the drug, which has been shown to improve the symptoms and difficulties which individuals with FXS experience such as delayed language /cognition, excessive eating, obesity, hypogonadism and delayed puberty.

Our double-blinded study will allow us to document potential benefits of the Metformin drug.

What the participants will do?

Commit to a 4-month study which includes, 3 clinic visits, and 5 phone calls while taking the Metformin orally.

Complete various tasks, questionnaires, and examinations by a physician/research team. Participants will also have blood drawn, as well as urine and stool samples taken.

Who can participate?

Individuals aged 6-25 who have been diagnosed with FXS (and who fit the inclusion/exclusion criteria).

How to participate?

If you would like to learn more, or would like to participate, contact our study coordinator at the University of Alberta by phone 780-492-9461 or email metcoord@ualberta.ca or, our study coordinator at CHU Sainte-Justine in Montreal by phone 514-345-4931 ext. 2789 or email maryse.thibeault@recherche-ste-justine.qc.ca.

You can also visit our website.

Together we may be able to give those diagnosed with FXS (and their families) a better life experience.

Project

“A Double-Blind, Placebo-Controlled Trial of Metformin in Individuals with Fragile X Syndrome (FXS)”.

The principal investigators of this study are Dr. Francois Bolduc, MD, PhD, FRCPC, in the Department of Pediatrics at the University of Alberta and Dr. Sebastien Jacquemont, MD, in the Department of Genetic at CHU Sainte-Justine in Montreal. www.bolduclab.com

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Updated on 2/26/2020
Created on 2/26/2020
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