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Centre de recherche
Tuesday, February 24 2015
Press release

A 5-year financing to support Alexey Pshezhetsky’s leading program in glycomics

Investigating the role of blood sialic acids in atherosclerosis and diabetes

MONTRÉAL, February 24, 2015 – The Networks of Centers of Excellence of Canada announced on February 6, 2015, that its newly selected national research network GlycoNet was receiving $27.3 million over five years to develop new drugs and vaccines for conditions such as influenza, genetic diseases and diabetes, building on Canada's international leadership in glycomics.

Dr. Alexey Pshezhetsky, a world-leader in glycomics active as a researcher at CHU Sainte-Justine and a full professor in the Department of Paediatrics and the Department of Biochemistry and Molecular Medicine of Université de Montréal, was among the investigators that were awarded the financing announced for the network. Dr. Pshezhetsky will be working together with his collaborators from GlycoNet to understand if changes in blood sialic acids represent a risk factor for atherosclerosis and diabetes in human population.

So far, Dr. Pshezhetsky and his team have established a link between sialic acids –a particular type of sugar– and common metabolic disorders, diabetes and atherosclerosis. More specifically, they have discovered that sialylation of surface receptors and blood cholesterol particles plays a major role in the development of insulin resistance, which contributes to Type 2 diabetes and the formation of atheroma, which restricts blood flow in cases of atherosclerosis. Dr. Pshezhetsky’s program should gradually evolve into studying the roles played by sialic acids in health and disease at a global scale.

Atherosclerosis is the leading cause of cardiovascular diseases in general. Diabetes is one of the major causes of premature illness and death, with the total deaths from this disease projected to rise by more than 50% in the next 10 years, according to the World Health Organization.

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Source
Centre de recherche du CHU Sainte-Justine
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communications@recherche-ste-justine.qc.ca

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À propos du Centre de recherche du CHU Sainte-Justine

Le Centre de recherche du CHU Sainte-Justine est un établissement phare en recherche mère-enfant affilié à l’Université de Montréal. Axé sur la découverte de moyens de prévention innovants, de traitements moins intrusifs et plus rapides et d’avenues prometteuses de médecine personnalisée, il  réunit plus de 200 chercheurs et 350 étudiants de cycles supérieurs et postdoctorants. Le centre est partie intégrante du Centre hospitalier universitaire Sainte-Justine, le plus grand centre mère-enfant au Canada et le deuxième centre pédiatrique en importance en Amérique du Nord. Détails sur le : chusj.org

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Updated on 2/24/2015
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