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Centre de recherche
Monday, November 15 2021
Press release

New biomarkers for type 1 diabetes

A new CHU Sainte-Justine study identifies circulating proteins as potential therapeutic targets and screening tools

MONTREAL, November 15, 2021 – A research team led by Dr. Despoina Manousaki of the CHU Sainte-Justine Research Centre and the Université de Montréal has identified three circulating proteins as promising molecules for the development of drugs and early detection tools for patients with type 1 diabetes. Type 1 diabetes is an autoimmune disease characterized by a deficiency of insulin secretion by the pancreas. This type affects about 10% of people living with diabetes, but from birth, very few biomarkers exist to predict the risk of developing the disease.

“Our analyses revealed that higher levels of SIRPG and IL27EBI3 proteins increase the risk of developing type 1 diabetes and higher levels of CTRB1 decrease the risk of developing the disease,” says Dr. Manousaki, a clinician-researcher in pediatric endocrinology at CHU Sainte-Justine and a clinical assistant professor in the Department of Pediatrics at the Université de Montréal.

The results of this work are presented in Diabetes Care.

Huge potential

Circulating proteins are an underexplored source of biomarkers, but their potential is enormous.

“Because drugs bind strongly to proteins circulating in the blood, they are attractive targets for developing new therapies. Reliable test methods for measuring circulating proteins also exist, making them a possible means of early detection of those at high risk of type 1 diabetes,” explains Dr. Nahid Yazdanpanah, a research associate in Dr. Manousaki's lab and first author of the study.

To characterize these biomarkers, Dr. Manousaki and her team carried out a Mendelian randomization study to identify proteins in the bloodstream that influence the risk of developing type 1 diabetes. This technique uses known genetic variations within a population to examine the causal effect of a variable on disease risk factors.

First, the research team mined a database to identify the genetic determinants of 1,600 circulating proteins. Then, they analyzed genomic data from 9,684 patients with type 1 diabetes and 15,743 controls to assess whether any of these proteins were associated with type 1 diabetes risk.

“Based on our results, we observe that an increase in plasma SIRPG is associated with an almost 60% increase in the risk of developing type 1 diabetes, while an increase in IL27EBI3 doubles the risk. Conversely, a higher CTRB1 level has a protective effect with a nearly 20% decrease in the risk of developing the disease,” indicates Dr. Manousaki.

According to Dr. Manousaki, “We need further research to validate these candidate proteins in case-controlled cohorts of type 1 diabetes, but these proteins have the potential to advance precision medicine for individuals at risk of developing this condition.” 

About this study

The article “Clinically-relevant circulating protein biomarkers for type 1 diabetes: evidence from a two-sample Mendelian randomization,” written by Nahid Yazdanpanah was published in Diabetes Care in November 2021. The study was funded by the Pediatric Endocrine Society.

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About the CHU Sainte-Justine Research Centre

The CHU Sainte-Justine Research Centre is a leading mother-child research institution affiliated with the Université de Montréal. It brings together more than 210 research investigators, including over 110 clinician-scientists, as well as 450 graduate and postgraduate students focused on finding innovative prevention means, faster and less invasive treatments, as well as personalized approaches to medicine. The centre is part of CHU Sainte-Justine, which is the largest mother-child centre in Canada.

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CHU Sainte-Justine
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Source:

Maude Hoffmann
Communications, CHU Sainte-Justine Research Centre
maude.hoffmann.hsj@ssss.gouv.qc.ca

Media resource person:

Florence Meney
Assistant to the Director of Communications – External Media Liaison
CHU Sainte-Justine
Tel: 514-755-2516
florence.meney.hsj@ssss.gouv.qc.ca 

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Updated on 11/15/2021
Created on 11/15/2021
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