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Why a Pediatric Formulations Centre?

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Many medicines used in children are not available in pharmaceutical forms adapted to their needs.

Indeed, most oral medications are produced for adults as tablets and capsules, which lack the flexibility to meet dosage requirements for the spectrum of ages and sizes, ranging from neonates to adolescents.

Furthermore, most children under the age of 8 are unable to swallow pills.


Compounding

Approved adult forms often need to be modified in some manner to administer the desired dose to children.

When this happens, the adult form is manipulated by either a health care provider, such as a pharmacist, or at home by parents or caregivers (e.g., grinding a tablet and sprinkling it into the fluid or a food vehicle such as applesauce).

This process is called compounding and is commonplace for those drugs that lack pediatric formulations.

Brief video on compounding

Food vehicles used to administer these compounded medicines, or to mask the bad taste of some formulations, can alter drug absorption.

We strive to contribute to making available to children of all ages convenient and high-quality pediatric products adapted to their needs that can spell the difference between successful treatment and therapeutic failure and prevent adverse drug events.

Children deserve the same standards as adults to have medicines adapted to their needs.

By increasing the number of medicines formulated for children, the GPFC aims to improve the efficacy, safety and compliance of medicines for children.

As a trusted partner to all parties involved, the team endeavors to shape the environment to encourage drug development and the commercialization of pediatric formulations in Canada and elsewhere.

The GPFC is the voice of Canadian children of all ages, aiming to ensure the availability of treatments which meet their needs..


FAQ


What is compounding?

Compounding is the process where two or more ingredients are mixed to create a final product in an appropriate form for dosing.

It can involve the alteration of the form and strength of the commercially available product and can include reformulation to allow for a new route of administration.


What is an excipient?

Excipients are inactive substances that are formulated alongside the active ingredient of a medication to create a final product in an appropriate form for dosing.

They can be included, for example, to stabilize the medicine or to aid in the manufacturing process.


What is the difference between forms and formulations?

Formulations is the term denoting the combination of an active pharmaceutical ingredient (API) with other non-active constituents – termed excipients – to create a medication.

Form refers to the overall physical configuration of a medication (e.g., tablet, powder, capsule or liquid).


What is compounding?

Compounding is the process where two or more ingredients are mixed (one has to be a medicine) to create a final product in an appropriate form for dosing.

It can involve the alteration of the form and strength of the commercially available product and can include reformulation to allow for a new route of administration.

About this page
Updated on 5/28/2020
Created on 5/28/2020
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