The mass spectrometry platform of the Pharmacology Research Unit (URP) is a platform specialized in the monitoring assay of drug molecules and/or their metabolites in different biological matrices. This unit is part of the common scientific platforms of the Centre de recherche du CHU Sainte-Justine Research Center.
In January 2021, an integrated pharmacology platform, supported in part by the Centre de recherche du CHU Sainte-Justine was launched to assist researchers in pharmacometrics projects associated with clinical trials or for molecule dosing in translational research projects.
The platform has dedicated expert staff and state-of-the-art equipment such as tandem mass spectrometers (MS/MS) to assist researchers drug monitoring in a pediatric context of limited sampling volume.Staff have extensive experience in dosing components (e.g., ruxolitinib, trametinib, busulfan, cyclosporine, tacrolimus, isavuconazole, alpelisib, cephalexin ) and in the measurement of different parameters such AUC, Cmax, Cmin and free fraction. URP team offers its full support to make this expertise available to research projects of the scientific community.
Equipments
- HPLC (High performance liquid chromatography system) Agilent coupled to fluorescence (FLD) and diode array (DAD) detectors
- HPLC (High performance liquid chromatography system) Agilent coupled to tandem mass spectrometers
Services
- Development and validation of methods for pharmacological assays in different biological matrices (e.g. plasma, breast milk)
- Pharmacological assays using existing methods in the literature or in the clinical laboratory setting
- Consulting service to initiate a project
Clientele
Academic, governmental or corporate environment interested in a pharmacology analysis service.
Financial partners
- Grandir en santé Fund
- Canada Foundation for Innovation (CFI)
- Fondation CHU Sainte-Justine
Partner institutions
- OPTILAB
- CHU Sainte-Justine
Team
Manager
Audrey Denoncourt, LC-MS/MS specialist
audrey.denoncourt.hsj@ssss.gouv.qc.ca
Scientific Director
Yves Théorêt
yves.theoret@umontreal.ca
Head– Scientific Platforms
Valérie Villeneuve
valerie.villeneuve.hsj@ssss.gouv.qc.ca
Price List
Pharmacology Research Unit (PRU)
| Service* |
| Faisability Study |
Personalized prices for each project according to the number of molecules to be assayed, the complexity of the matrix, the number of samples, the duration of the project and the researcher's affiliation (internal, academic, private). |
| Bioanalytical Method Development and validation |
| Preparation and Extraction of the molecules to monitor in the samples (liquid-liquid or solid phase extraction (LLE or SPE)) |
| Quantitative assay of samples from an existing or newly developed method |
| *The client understands and agrees that the services of the platform should not be used to make a clinical diagnosis as part of standard patient care. |