Researcher

Title

• Clinical Assistant Professor in Pediatrics, Neonatologist, Department of Neurosciences and Pediatrics, Faculty of Medicine, CHU Sainte-Justine, Université de Montréal, 2018

Internship opportunity(ies)

• Neuroprotective strategies to prevent long-term cognitive deficits induced by cerebellar injury - MSc / PhD

• 2013 - ..., PhD in Neurosciences, The University of British Columbia, Vancouver, Canada
• 2010 - 2012, Post-doctorate, Neonatal-Perinatal Medicine Fellow Program (PGY-4 and 5), Paediatric subspecialty, CHU Ste-Justine, Université de Montréal, Montréal, Canada
• 2006 - 2009, Post-doctorate, Residency Program (PGY-1 to PGY-3), General Paediatric Specialty, CHU Ste-Justine, , Université de Montréal, Montréal, Canada
• 2001 - 2005, Doctorate, Doctor in Medicine - M.D., General Medicine, Université de Montréal, Montréal, Canada
• 2000 - 2002, Master's Thesis, Master in Sciences with Honours, Neurosciences, Université Laval, Québec, Canada
• 1997 - 2000, Bachelor's, Bachelor in Biology, Biotechnology, Université de Sherbrooke, Sherbrook, Canada

• Neuro-inflammation
• Cerebellar injuries
• Microglial response
• Preterm
• Haemorrhage
• Central nervous system development
• Neuro-protection
• Brain-gut axis

Career Summary

After her bachelor and master’s in science, Sophie Tremblay started her MD. During her training as a paediatrician and neonatologist, she developed an interest in preterm brain development, having seen first hand the devastating consequences of neonatal brain damages on the extremely preterm infants. She therefore dedicated herself to establish a research program to develop translational pre-clinical models that will ultimately improve the care and health of infants born preterm. She is particularly interested in understanding how the developing brain is influenced by the innate immune system and inflammatory stressors.

Awards and Distinctions

• 2018 Faculty of Medicine Graduate Award
  University of British Columbia, Vancouver
• 2016-2017 Four Year Fellowships for PhD Student
  University of British Columbia, Vancouver
• 2013-2016 Four Year Fellowships for PhD Student, Tuition fees coverage
  University of British Columbia, Vancouver
• 2014 NewGen Mentorship Award
  Centre for Molecular Medicine and Therapeutics, Vancouver
• 2013-2016 Frederick Banting and Charles Best Canadian Doctoral Award
  Canadian Institutes of Health Research, 3 years funding
• 2013-2016 Doctoral Award for Professional Degree, CIHR Award supplement
  Fond de la Recherche en Santé du Québec, 3 years funding
• 2013 College for Interdisciplinary Studies Graduate Awar
  Faculty of Graduate Studies, University of British Columbia
• 2012 Prize Claude-Roy, Best Research Fellowship
  CHU Ste-Justine, Université de Montréal
• 2010 Rising Researcher Support Program Award
  Canadian Child Health Clinician Scientist Program (CCHCSP)
• 2009 Annual Canadian Paediatric Resident Research Competition (1st place)
  Manitoba Institute of Child Health and the Department of Pediatrics
• 2009 Paediatric Resident Research Competition (1st place)
  CHU Ste-Justine Pediatric Department, Montréal
• 2000-2002 Master Research Award
  Natural Sciences and Engineering Research Council of Canada (NSERCC), 2 years Funding
• 1998-1999 CEGEP Study Scholarship
  UES Section Local 800, Québec
• Summer 1998 Award to the Best Summer Student Academic File
  Leukemia Research Foundation of Canada
• Summer 1998 Sciences Summer Student Awar
  Employment and Career Canada
• 1994-1997 Award in Sciences and Engineering: Excellence of the Academic File
  Industry Canada

Major funding

• CHU Sainte-Justine Foundation
• Foundation of Stars

Presentations

• Fragilité Cérébelleuse de l’Extrême Prématuré aux Insultes Périnatales: Modélisation et Neurotoxicité Microgliale. CHU Ste-Justine Research Centre Job talk. Montréal, Canada. April 2016
• Vulnérabilité Cérébelleuse de l’Extrême Prématuré aux Insultes Périnatales: Modéliser pour mieux protéger. Pediatric département, CHU Québec Job talk. Québec, Canada. November 2016
• Microglial Response and Long-Term Behavioral Outcomes in a Translational Perinatal Mouse Model of Cerebellar Hemorrhage and Inflammation. Pediatric Academic Societies Annual Meeting. Baltimore, USA. International 2016
• Microglial Response and Long-Term Behavioral Outcomes in a Translational Perinatal Mouse Model of Cerebellar Hemorrhage and Inflammation. Canadian National Perinatal Research Meeting.  Banff, Canada. National 2016
• The Onset of Inflammatory Perinatal Stressors Has a Significant Impact on Motor Behavioural Outcomes in Mouse. Pediatric Academic Societies Annual Meeting. San Diego, USA. International 2015

Publications

• Tremblay S, Richter L, Pai, A, Vafaei R, Ellegood J, Lerch JP, Goldowitz D. Systemic Inflammation combined with neonatal cerebellar haemorrhage aggravates long-term structural and functional outcomes in a mouse model. Brain, Behavior and Immunity. 2017. Nov 66:257-276. doi: 10.1016/j.bbi.2017.07.013. Epub 2017 Jul 27.
• Tremblay S*, Ranger M*, Chau CM, Ellegood J, Lerch JP, Holsti L, Goldowitz D**, Grunau R**. Repeated exposure to sucrose for procedural pain in mouse pups leads to long-term widespread brain alterations. Pain. 2017. Aug 158(8): 1586-1598. doi: 10.1097/j.pain.0000000000000961. Editor’s choice publication.
• Tahiri H, Omri S, Yang C, Duhamel F, Samarani S, Ahmad A, Vézina M, Bussières M, Vaucher E, Sapieha P, Hickson G, Hammaji K, Lapointe R, Rodier F, Tremblay S, Royal I, Cailhier JF, Chemtob S, Hardy P. Lymphocytic Microparticles Modulate Angiogenic Properties of Macrophages in Laser induced Choroidal Neovascularization. Scientific Reports. 2016. Nov 6:37391.
• Moussa A, Luangxay Y, Tremblay S, Lavoie J, Aube G, Savoie E, Lachance C. Videolaryngoscope for Teaching Neonatal Endotracheal Intubation: A Randomized Controlled Trial. Pediatrics. 2016. Mar 137(3):e2015-2156. doi: 10.1542/peds.2015-2156. Epub 2016 Feb 12.
• Tremblay S, Milaudi K, Chaychi S, Favret S, Binet F, Polosa A, Lachapelle P, Chemtob S, Sapieha P. Systemic Inflammation Perturbs Developmental Retinal Angiogenesis and Neuroretinal Function. Investigative Ophthalmology and Visual Science. 2013. Dec 17: 54(13):8125-8139.
• Leboeuf D, Tremblay S, Rezende F, Juan AM, Stahl A, Joyal JS, Milot E, Kaufman RJ, Guimond M, Kennedy TE and P Sapieha. Neuronal ER Stress Impedes Myeloid-Cell-Induced Vascular Regeneration through IRE1a Degradation of Netrin-1. Cell Metabolism. 2013. 17(3):353-371. Highlight publication.
• Zaniolo K, Sapieha P, Shao Z, Stahl A, Zhu T, Tremblay S, Picard E, Madaan A, Blais M, Lachapelle P, Mancini J, Hardy P, Smith LE, Ong H, Chemtob SA. Ghrelin Modulates Physiological and Pathological Retinal Angiogenesis via GHSR-1a. Investigative Ophtalmology and Visual Science. 2011. 52(8) : 5378-86.
• Honoré JC, Kooli A, Hou X, Hamel D, Rivera JC, Picard E, Hardy P, Tremblay S, Varma D, Jankov R, Mancini J, Balazy M, Chemtob S. Sustained Hypercapnia Induces Cerebral Microvascular Degeneration in the Immature Brain through Induction of Nitrative Stress. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology. 2010. 298(6) : R1522-30.
• Sapieha P, Sirinyan M, Hamel D, Zaniolo K, Joyal JS, Cho JH, Honoré JC, Kermorvant-Duchemin E, Varma DR, Tremblay S, Leduc M, Rihakova L, Hardy P, Klein WH, Mu X, Mamer O, Lachapelle P, Di Polo A, Beauséjour C, Andelfinger G, Mitchell G, Sennlaub F, Chemtob S.A. The Succinate Receptor GPR91 in Neurons Has a Major Role in Retinal Angiogenesis. Nature Medicine. 2008. 14(10) : 1067-76. Nature Meds Top Ten Articles for 2008.
• Kooli A, Kermorvant-Duchemin E, Sennlaub F, Bossolasco M, Hou X, Honoré JC, Dennery PA, Sapieha P, Varma D, Lachapelle P, Zhu T, Tremblay S, Hardy P, Jain K, Balazy M, Chemtob S. Trans-Arachidonic Acids Induce a Heme Oxygenase-Dependent Vasorelaxation of Cerebral Microvasculature. Free Radical Biology and Medicine. 2008. 44(5):815-25.