Anti-infectives are among the most commonly used therapeutic agents. Therapeutic drug monitoring (TDM) combines quantification of drug concentrations in the blood, pharmacological interpretation and therapeutic guidance. In the era of precision medicine and the emergence of antimicrobial resistance, TDM combined with pharmacokinetic/pharmacodynamic population models is enabling the development of model-informed precision dosing, and is playing an increasingly important role in treatment optimization.
My research project aims to develop a model-informed precision dosing program for anti-infectives. This program focuses more specifically on improving the quality of care in vulnerable populations (pediatrics, intensive care units, etc.). This research program, subdivided into four distinct and complementary axes, will enable the development of model-informed precision dosing of many anti-infectives not currently available in Quebec and Canada, in order to individualize dosages and optimize pharmacotherapy.
Career Summary
PhD holder in clinical research and public health in pharmacokinetics and author of some 50 scientific articles, Amélie Marsot is Associate Professor and Director of the STP2 Laboratory in the Faculty of Pharmacy at the Université de Montréal. She was previously a researcher in the Clinical Pharmacology Department of Assistance publique - Hôpitaux de Marseille and a part-time lecturer at the Aix-Marseille University.
Laboratory
STP2 Lab