Hélène Decaluwe , M.D. , Ph.D. , FRCPC
    Hélène Decaluwe
    Research Axis
    Viral and Immune Disorders and Cancers
    Research Theme
    Hematopoietic stem cell transplantation and immunotherapy

    514 345-4713

    514 345-4897


    • Deputy Head, Research Axis, Immune Disorders and Cancers, CHU Sainte-Justine Research Center 
    • Assistant Clinical Professor, Allergy-Immunology-Rheumatology Unit, Department of Pediatrics, University of Montreal.
    • Clinician Scientist, CHU Sainte-Justine Research Center.

    Internship opportunity(ies)


    • PhD (Immunology), Pasteur Institute, Université Pierre et Marie Curie (UPMC), Paris, 2006-2010.
    • Master’s (Immunology), Faculty of Medicine, Necker Hospital for Sick Children, UPMC, Paris, 2004-2005.
    • Fellowship in Pediatric Immunology and Rheumatology, Necker Hospital for Sick Children, Paris, 2003-2005.
    • Specialized Studies Diploma in Pediatrics, University of Montreal, 1999-2003.
    • MD, McGill University, 1994-1999.

    Research Interests

    The ability to develop and maintain a population of memory cells after an infection or vaccination is the hallmark of adaptive responses and the basis of preventive vaccination against infectious pathogens. Understanding the mechanisms implicated in the differentiation of CD8+ T -lymphocytes is therefore essential for improving immunological memory after vaccination and developing novel cell-based therapies for the treatment of chronic viral infections and cancer. For this reason, our research interests focus, on the one hand, on the study of cell factors that are essential for eliminating a viral pathogen or a tumoral antigen and, on the other hand, on generating and maintaining antigen-specific memory CD8+ T -lymphocytes. By using transgenic mice, we are concentrating our efforts on the role of common gamma-chain dependent cytokines in the differentiation and generation of memory CD8+ T -lymphocytes after an viral infection or vaccination. We are also interested in the cytotoxic mechanisms that are essential for the effective elimination of viral or tumoral antigens, and on the development of T cell exhaustion in these contexts. Finally, we are interested in the kinetics of the reconstitution and function of CD8+ T -lymphocytes after bone marrow transplant.

    Awards and Distinctions

    • Clinical Research Scholar Junior 1 Award, Fonds de Recherche en Santé du Québec (FRSQ), 2012-2016
    • Canadian Child Health Clinician Scientist Career Development Award (CCHCSP), 2011-2015
    • Cole Foundation Transition Award, 2011-2014
    • Research Award, Canadian Louis Pasteur Foundation, 2008-2010
    • Doctorate Award, Fonds de Recherche en Santé du Québec (FRSQ), 2008-2009
    • Canadian Institutes of Health Research (CIHR) Industry Partnered Award, 2006-2008
    • Junior Research Fellowship Award, Association de Recherche sur le Cancer, 2006
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Edited by Hoffmann Maude

Created on 9/18/2014
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