• Français

Research Axes

Brain and Child Development Axis

Mission and themes

CHU Sainte-Justine is the major pediatric centre in Quebec for the clinical evaluation of neurodevelopmental disorders, such as intellectual disability, epilepsy and autism spectrum disorders. A second important focus is to understand the development of psychopathologies. It has been estimated that one out of five children has attention or communication problems, anxiety, is hyperactive of impulsive or shows aggressive behaviour before adolescence.

The main goals of this axis are to:

  1. identify genetic and environmental determinants of neurodevelopmental disorders;
  2. understand the impact of these determinants on the development of neuronal circuits;
  3. characterize neurodevelopment phenotypes in children with the goal to find biomarkers allowing early diagnosis and intervention of children at risk; and
  4. combine the data obtained through patient phenotypes and functional analysis to inform the development of new therapeutic approaches/interventions.

In order to achieve these goals the axis integrates multiple and complementary approaches, including genetic and epigenetic analyzes, observation of the development of neuronal circuits in model systems, brain imaging, neuropsychological evaluations, evaluation of psychopathologies, longitudinal follow-up of the development of large birth cohorts and the experimentation of preventive interventions.

The integration of these approaches has become essential for studying the development of brain pathologies and their prevention. The axis has two major research themes: the development of psychopathologies and neurodevelopmental diseases.


Neurodevelopmental diseases

Development of psychopathologies

About this page
Updated on 9/21/2020
Created on 8/8/2014
Alert or send a suggestion

Every dollar counts!

Thank you for your generosity.

It's people like you that allow us to accelerate research and heal more children better every year and, as such, offer among the best healthcare in the world.

It's also possible to give by mail or by calling toll-free

1-888-235-DONS (3667)

Contact Us

514 345-4931


© 2006-2014 CHU Sainte-Justine.
All rights reserved.
Terms of Use, Confidentiality, Security


Les informations contenues dans le site « CHU Sainte-Justine » ne doivent pas être utilisées comme un substitut aux conseils d’un médecin dûment qualifié et autorisé ou d’un autre professionnel de la santé. Les informations fournies ici le sont à des fins exclusivement éducatives et informatives.

Consultez votre médecin si vous croyez être malade ou composez le 911 pour toute urgence médicale.

CHU Sainte-Justine